%0 Journal Article
%T VETC癌巢型肝细胞癌的研究进展
%T Research progress of VETC carcinoma nest-type hepatocellular carcinoma
%A 杨建荣,刘天奇,郑树森,董小锋
%A YANG,Jian rong
%A LIU,Tian qi
%A ZHENG,Shu sen
%A et al.
%J 中国临床新医学
%J CHINESE JOURNAL OF NEW CLINICAL MEDICINE
%@ 1674-3806
%V 14
%N 6
%D 2021
%P 529-533
%K 肝细胞癌;血管包绕肿瘤细胞巢;诊断;治疗;预后
%K Hepatocellular carcinoma(HCC);Vessels encapsulated tumor clusters(VETC);Diagnosis;Therapy;Prognosis
%X [摘要] 肝癌的复发转移是影响肝癌患者预后的关键。血管包绕肿瘤细胞巢(VETC)癌巢型肝细胞癌的转移方式无法用上皮-间质转化(EMT)理论来解释,其可以内皮细胞包绕肿瘤细胞团的形式发生整体转移,转移过程中肿瘤细胞不会发生EMT,VETC癌巢型肝细胞癌更易发生转移,转移效率更高,术后更易复发,预后更差。该文对VETC癌巢型肝细胞癌的分型、分子学特征、诊断、治疗及预后等进行评价和介绍,从而提高临床医师及研究人员对该类肝癌诊治的认识。
%X [Abstract] Relapse and metastasis are the key factors affecting the prognosis of patients with hepatocellular carcinoma(HCC). The metastasis mechanisms of vessels encapsulated tumor clusters(VETC) carcinoma nest-type HCC can not be explained by the theory of epithelial-to-mesenchymal transition(EMT). In VETC carcinoma nest-type HCC, tumor cells do not metastasize through EMT, but metastasize to other organs in carcinoma nest form in which VETC carcinoma nest-type HCC is encapsulated by endothelial cells. VETC carcinoma nest-type HCC is more likely to have metastasis and higher metastatic efficiency, and is more likely to relapse after operation, resulting in a worse prognosis. This paper evaluates and introduces the classification, molecular characteristics, diagnosis, treatment and prognosis of VETC carcinoma nest-type HCC, so as to improve the understanding of clinicians and researchers on the diagnosis and treatment of VETC carcinoma nest-type HCC.
%R 10.3969/j.issn.1674-3806.2021.06.01
%U http://www.zglcxyxzz.com/ch/reader/view_abstract.aspx
%1 JIS Version 3.0.0