| 摘要: |
| ［摘要］ 目的 探讨交叉配血不合原因以及相应的处理方法，以指导临床安全有效合理用血。方法 对2014-01～2016-12在该院收治需行输血治疗的170例交叉配血不合患者进行回顾性分析，总结输血前交叉配血不合原因，归纳处理方法。结果 170例疑难交叉配血标本中，不规则抗体88例（51.76%），自身抗体62例(36.47%)，ABO亚型14例(8.24%)，蛋白凝集4例（2.35%），药物原因2例(1.18%)。不规则抗体中，Rh系统32例(联合抗体3例），MNSs系统19例，Lewis系统6例，Kidd系统和Diego系统各占1例，多种抗体7例，未能检出抗体特异性16例，抗体阳性未鉴定抗体特异性6例。ABO亚型14例中有稀有血型类孟买3例。采取配合性输注各种血液成分，患者均及时得到有效救治。结论 交叉配血不合主要是由同种不规则抗体，其次是自身抗体等原因引起。根据交叉配血不合的具体原因采取相应措施，指导临床确定输血方案，选择合适的血液进行输注，保障输血的安全有效。 |
| 关键词: 交叉配血不合 不规则抗体 自身抗体 ABO亚型 输血策略 |
| DOI：10.3969/j.issn.1674-3806.2017.08.04 |
| 分类号:R 457.1 |
| 基金项目:广西卫计委科研课题(编号:Z2012304) |
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| Analysis of 170 cases with cross-matching incompatibility and the strategy of blood transfusion |
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WEI Liang-ying, LI Hai-lan, LUO Rui-xian, et al.
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Analysis of 170 cases with cross-matching incompatibility and the strategy of blood transfusion
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| Abstract: |
| ［Abstract］ Objective To discuss the causes of the cross-matching incompatibility and the relevant managing methods.Methods We retrospectively analyzed the data of 170 patients with cross-matching incompatibility who needed blood transfusion from the blood bank in our hospital from January 2014 to December 2016, and summarized the causes of cross-matching incompatibility before blood transfusion.Results In the 170 patients with cross-matching incompatibility, there were 88 cases with irregular antibody(51.76%), 62 cases with auto-antibodies(36.47%), 14 cases with ABO subtype(8.24%), 4 cases with protein aggregation(2.35%) and 2 cases with drug reason(1.18%). In the cases with irregular antibodies, there were 32 cases with Rh system(including 3 cases with joint antibodies), 19 cases with MNSs system, 6 cases with Lewis system, 1 case with Kidd, 1 case with Diego system, 7 cases with multiple antibodies. 16 cases failed to detect the antibodies, and 6 cases with unidentified antibodies.Conclusion The main cause of cross-matching incompatibility is the same irregular antibodies, followed by autoantibodies. Clinical blood transfusion schemes should be determined by the types and specific causes of the cross-matching incompatibility. |
| Key words: Cross-matching incompatibility Irregular antibodies Auto-antibodies ABO subtype Blood transfusion strategy |
