| 摘要: |
| ［摘要］ 目的 观察四联Hp根除治疗对十二指肠溃疡（DU）患者胃排空功能及炎症因子的影响。方法 将2015-02～2017-07该院收治的84例DU患者作为研究对象，依据随机数字表法将其分为两组，各42例。对照组采取奥美拉唑、阿莫西林、克拉霉素治疗，观察组则加以胶体果胶铋的四联Hp根除治疗。比较两组临床疗效、Hp根除率、治疗前后胃排空功能及炎症因子水平。结果 两组临床疗效、Hp根除率对比，观察组高于对照组，差异有统计学意义（P<0.05）。治疗前两组胃排空时间(T)、胃窦收缩频率（F）、热休克蛋白（HSP60）、肿瘤坏死因子-α(TNF-α)对比，差异无统计学意义（P>0.05）。治疗后观察组T、F、HSP60、TNF-α低于对照组，差异有统计学意义（P<0.05）。结论 将四联疗法用于DU治疗中根除Hp效果良好，并可提升DU患者胃排空功能，下调机体内炎症因子水平。 |
| 关键词: 十二指肠溃疡 四联疗法 胃排空功能 炎症因子 |
| DOI：10.3969/j.issn.1674-3806.2018.06.20 |
| 分类号:R 573.1 |
| 基金项目: |
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| Effects of quadruple Hp eradication therapy on gastric emptying function and inflammatory factors in patients with duodenal ulcer |
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YANG Ying-dong
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Department of Digestive System, Maternal and Child Health Hospital of Fuchuan Yao Autonomous County of Hezhou City, Guangxi 542700, China
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| Abstract: |
| ［Abstract］ Objective To observe the effects of quadruple helicobacter pylori(Hp) eradication therapy on gastric emptying function and inflammatory factors in patients with duodenal ulcer(DU). Methods 84 DU patients treated in our hospital from February 2015 to July 2017 were selected, and they were divided into the control group and the observation group by random number table method, with 42 cases in each group. The control group was given omeprazole, amoxicillin, and clarithromycin, while the observation group was treated with quadruple Hp eradication therapy with omeprazole, amoxicillin, clarithromycin and colloidal bismuth pectin. The eradication rate of Hp infection, gastric emptying function and the levels of inflammatory factors were compared between the two groups. Results The total effective rate and the eradication rate of the observation group were significantly higher than those of the control group(P<0.05). Before treatment, there were no significant differences in the gastric emptying time(T), antral contraction frequency(F), heat shock protein(HSP60) and tumour necrosis factor-α(TNF-α) between the two groups(P>0.05). After treatment, the levels of T, F, HSP60 and TNF-α in the observation group were significantly lower than those in the control group(P<0.05). Conclusion Quadruple therapy is effective in eradicating Hp, increasing gastric emptying function and down-regulating the levels of inflammatory factors for the patients with DU. |
| Key words: Duodenal ulcer Quadruple therapy Gastric emptying function Inflammatory factors |
