| 摘要: |
| ［摘要］ 目的 评价R-CHOP治疗EB病毒（Epstein-Barr virus,EBV）感染弥漫大B细胞淋巴瘤预后的影响。方法 检索了PUBMED(1994-04～2017-04)、CNKI(1994-04～2017-04)、Cochrane library(1994-04～2017-04)、WanFang Data(1996-12～2017-04)公开发表的关于R-CHOP治疗EBV阳性弥漫大B细胞淋巴瘤的相关研究文献，按照Cochrane质量评价系统评价纳入研究质量后，应用RevMan 5.0软件进行Meta分析。结果 共纳入7篇队列研究，其中EBV阳性弥漫大B细胞淋巴瘤140例，EBV阴性弥漫大B细胞淋巴瘤1 812例。Meta分析结果显示，EBV阳性弥漫大B细胞淋巴瘤组的总生存期（HR=3.24，95%CI=1.88～5.58，P<0.0001）、无病生存期（HR=1.83，95%CI=1.44～3.25，P=0.0002）均差于EBV阴性弥漫大B细胞淋巴瘤组。结论 在以美罗华治疗弥漫大B细胞淋巴瘤的时代，EBV阳性仍是患者的主要不良预后因素。R-CHOP治疗EBV阳性弥漫大B细胞淋巴瘤的疗效欠佳。EBV可能参与了弥漫大B细胞淋巴瘤的发生、发展的全过程。 |
| 关键词: 弥漫大B细胞淋巴瘤 R-CHOP EB病毒 Meta分析 |
| DOI：10.3969/j.issn.1674-3806.2018.09.10 |
| 分类号:R 733 |
| 基金项目: |
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| Meta-analysis of the effect of EBV on diffuse large B-cell lymphoma treated with R-CHOP |
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WEI Hua-ping
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Department of Oncology, Beijing Huairou Hospital, Beijing 101400, China
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| Abstract: |
| ［Abstract］ Objective To evaluate the effect of EB virus(EBV) on diffuse large B-cell lymphoma(DLBCL) treated with R-CHOP chemotherapy. Methods The domestic and abroad authoritative databases were retrieved to find the published literature of R-CHOP chemotherapy for EBV positive DLBCL in PUBMED (1994-04 ～ 2017-04), CNKI (1994-04～2017-04), Cochrane library(1994-04～2017-04) and WanFang Data(1996-12～2017-04). The quality of the included studies was assessed by the Cochrane system method and Meta-analysis was performed using RevMan 5.0 software. Results Seven randomized controlled trials involving 140 EBV-positive patients and 1812 EBV-negative patients were included. Meta-analysis indicated that EBV-positive group was worse than EBV-negative group in overall survival(HR=3.24, 95%CI=1.88～5.58, P<0.0001) and progression-survival(HR=1.83, 95%CI=1.44～3.25, P=0.0002). Conclusion In the era of R-CHOP chemotherapy for DLBCL, EBV-positive is still the main adverse prognostic factor. The efficacy of R-CHOP chemotherapy for DLBCL is still uncertain, and EBV may involve in the occurrence and development of DLBCL. |
| Key words: Diffuse large B-cell lymphoma(DLBCL) R-CHOP Epstein-Barr virus Meta-analysis |
