引用本文:程 立,李 晶,郭梦竹,牟 云,陈 念,于大海.E-cadherin在人和小鼠口腔癌发生发展及淋巴转移中表达的比较[J].中国临床新医学,2018,11(11):1094-1097.
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E-cadherin在人和小鼠口腔癌发生发展及淋巴转移中表达的比较
程 立,李 晶,郭梦竹,牟 云,陈 念,于大海
530021 南宁,广西医科大学附属口腔医院颌面外科(程 立,陈 念);530021 南宁,广西医科大学第一附属医院口腔科(李 晶,郭梦竹,于大海);545000 广西,柳州市中医医院口腔科(牟 云)
摘要:
[摘要] 目的 比较人与Balb/c小鼠口腔癌形成及颌下淋巴结转移过程中E-钙黏蛋白(E-cadherin)的表达情况。方法 采用免疫组化法检测人(24例)和小鼠(12例)正常口腔黏膜组织、口腔上皮异常增生组织、口腔鳞癌组织及口腔鳞癌颌下淋巴结转移灶中E-cadherin的表达情况。结果 人正常口腔黏膜E-cadherin的表达率为100.0%(24/24),口腔上皮异常增生组织E-cadherin表达率为87.5%(21/24),口腔鳞癌E-cadherin表达率为0.0%(0/24),颌下淋巴结转移灶中E-cadherin表达率为79.2%(19/24)。小鼠正常口腔黏膜E-cadherin的表达率为100.0%(12/12),口腔上皮异常增生组织E-cadherin表达率为83.3%(10/12),口腔鳞癌E-cadherin表达率为0.0%(0/12),颌下淋巴结转移灶中E-cadherin表达率为100.0%(12/12)。结论 E-cadherin的表达在人与小鼠具有相似性,随着病理恶性程度的升高,人和小鼠口腔癌各阶段组织中E-cadherin的表达率逐渐降低,但在颌下淋巴结转移灶中表达率升高,表明E-cadherin是参与口腔癌发生、发展及颌下淋巴结转移过程中的一个重要因子。
关键词:  E-钙黏蛋白  口腔鳞状细胞癌  淋巴结转移  小鼠  
DOI:10.3969/j.issn.1674-3806.2018.11.07
分类号:R 739.85
基金项目:国家自然科学基金资助项目(编号:81360407);广西自然科学基金资助项目(编号:2013GXNSFAA019182)
Comparison of E-cadherin expressions between human and mouse in the occurrence, development and lymph node metastasis of oral squamous cell carcinoma
CHENG Li, LI Jing, GUO Meng-zhu, et al.
Department of Oral and Maxillofacial Surgery, the Affiliated Stomatological Hospital of Guangxi Medical University, Nanning 530021, China
Abstract:
[Abstract] Objective To compare the expressions of E-cadherin in different oral carcinogenesis stages and lymph node metastasis between human and mouse models. Methods Immunohistochemical staining was used to detect the expressions of E-cadherin in normal oral mucosae, oral dysplasia, oral squamous cell carcinomas(OSCC) and lymph node metastases in human beings(n=24) and mice(n=12), respectively. Results The expression rates of E-cadherin in normal oral mucosa, dysplasia, OSCC and lymph node metastasis were 100.0%, 87.5%, 0.0% and 79.2% in human beings and 100.0%, 83.3%, 0.0% and 100.0% in mice. Conclusion  The expressions of E-cadherin are similar in the same pathological stages of human beings and mice respectively. The expression rates of E-cadherin are decreased gradually in both human beings and mice with the increased degree of pathological malignancy, but are increased in lymph node metastases. These results indicate that E-cadherin may play an important role in the occurrence and development of OSCC and submandibular lymphatic node metastase.
Key words:  E-cadherin  Oral squamous cell carcinoma(OSCC)  Lymph node metastasis  Mouse  Human