引用本文:刘 艳(综述),许 路(审校).miRNA在神经胶质瘤中作用的研究进展[J].中国临床新医学,2018,11(11):1163-1167.
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miRNA在神经胶质瘤中作用的研究进展
刘 艳(综述),许 路(审校)
214028 江苏,无锡卫生高等职业技术学校护理系(刘 艳),行政(许 路)
摘要:
[摘要] 神经胶质瘤在原发性神经系统肿瘤中发病率高,传统治疗方法有一定的局限性,预后差。寻求新的分子基因靶点成为治疗胶质瘤新的突破点。研究发现非编码小RNA(microRNA,miRNA)参与了与肿瘤增殖、凋亡、转移、血管生成、免疫应答等相关的所有过程。其可通过抑制特定靶基因表达,而发挥促癌或抑癌作用。该文对近年来miRNA在胶质瘤基础研究中所取得的进展以及在临床诊治过程中的应用作一综述。
关键词:  微小核糖核酸  神经胶质瘤  治疗方法  靶基因
DOI:10.3969/j.issn.1674-3806.2018.11.29
分类号:R 739.41
基金项目:江苏省无锡市卫生计生委科研面上项目(编号:MS201765)
Research progress of miRNA in glioma
LIU Yan, XU Lu
Department of Nursing, Health Advanced Vocational & Technical School of Wuxi City, Jiangsu 214028, China
Abstract:
[Abstract] The incidence of glioma is high in primary nervous system tumors. Traditional therapeutic methods have certain limitations for the tumor, and the prognosis of the therapies are poor. Looking for novel molecular target genes is a new breakthrough treatment for glioma. Studies find that small non-coding RNA(miRNA) participates in all the processes associated with cancer, including proliferation, apoptosis, metastasis, angiogenesis and immune response. miRNA plays a role in promoting or inhibiting tumors by inhibiting specific target gene expressions. In this paper,we review the recent progress of miRNA in glioma basic research and the application of miRNA in clinical diagnosis and treatment for glioma.
Key words:  MicroRNA(miRNA)  Glioma  Therapeutic method  Target gene