引用本文:安勇鹏,雷军旗.慢性阻塞性肺疾病合并侵袭性肺曲霉菌病的危险因素分析[J].中国临床新医学,2018,11(12):1240-1242.
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慢性阻塞性肺疾病合并侵袭性肺曲霉菌病的危险因素分析
安勇鹏,雷军旗
475000 河南,开封市中心医院呼吸内科
摘要:
[摘要] 目的 探讨慢性阻塞性肺疾病(COPD)合并侵袭性肺曲霉菌病(IPA)的危险因素。方法 采用病例对照研究方法,选取2015-05~2018-05该院呼吸内科住院的COPD合并IPA的住院患者24例为病例组,以年龄为匹配因素(±2岁),按1∶2的比例选取同期住院的COPD患者48例为对照组,采用条件Logistic回归分析对COPD合并IPA的危险因素进行分析。结果 单因素分析结果显示COPD频繁急性加重、糖尿病、慢性肾功能不全、应用广谱抗生素≥2周、应用糖皮质激素为COPD合并IPA的危险因素(P<0.10);采用条件Logistic分析,糖尿病、应用广谱抗生素≥2周、应用糖皮质激素为COPD合并IPA的独立危险因素(OR=7.384,6.681,32.354,P<0.05)。结论 糖尿病、应用广谱抗生素≥2周、应用糖皮质激素为COPD合并IPA的独立危险因素。
关键词:  慢性阻塞性肺疾病  侵袭性肺曲霉菌病  危险因素
DOI:10.3969/j.issn.1674-3806.2018.12.18
分类号:R 543.5
基金项目:
Rrisk factors of chronic obstructive pulmonary disease accompanied with invasive pulmonary aspergillosis
AN Yong-peng, LEI Jun-qi
Department of Respiratory Medicine, Kaifeng Central Hospital, Henan 475000, China
Abstract:
[Abstract] Objective To investigate the risk factors of chronic obstructive pulmonary disease(COPD) accompanied with invasive pulmonary aspergillosis(IPA). Methods This case control study included 24 patients with COPD accompanied with invasive pulmonary aspergillosis(the observation group) in the Department of Respiratory Medicine of Kaifeng Central Hospital from May 2015 to May 2018. Other 48 COPD patients who hospitalized at the same time and were matched with age(±2 years) and with the ratio of 1∶2 were collected as the control group. Logistic regression analysis was used to evaluated the risk factors of COPD accompanied with IPA. Results Single factor analysis showed that the significant factors of COPD accompanied with IPA were acute exacerbation of COPD, diabetes mellitus, chronic renal failure, duration of broad-spectrum antibiotic use≥ two weeks and systemic use of steroids(P<0.10). Conditional Logistic regression analysis showed that diabetes mellitus and systemic use of steroids were the independent risk factors of COPD accompanied with IPA(OR=7.384, 6.681, 32.354, P<0. 05). Conclusion Diabetes mellitus, the duration of broad-spectrum antibiotic use≥two weeks and systemic use of steroids are the independent risk factors of COPD accompanied with IPA.
Key words:  Chronic obstructive pulmonary disease(COPD)  Invasive pulmonary aspergillosis(IPA)  Risk factors