| 摘要: |
| ［摘要］ 小分子RNA(microRNA)是一类内源基因非编码单链小RNA分子，可通过转录后抑制调节细胞的增殖、分化、凋亡及免疫应答等重要生命过程。microRNA146a（miR146a）是最早被发现参与调节免疫反应的miRNA，它的异常表达与自身免疫性疾病的发生与发展密切相关，在自身免疫性疾病的研究中受到广泛关注，研究miR146a在自身免疫性疾病的作用机制有助于其诊断与治疗。该文对miR146a在自身免疫性疾病中作用的研究进展作一综述。 |
| 关键词: 自身免疫性疾病 小分子RNA 小分子RNA-146a |
| DOI：10.3969/j.issn.1674-3806.2018.12.29 |
| 分类号:R 593.2 |
| 基金项目:国家自然科学基金项目（编号：8146025） |
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| Research advances of microRNA146a in autoimmune diseases |
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SHI Yu-hong, REN Ya-fei, JIANG Ya-nian, et al.
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Department of Rheumatology and Immunology, the Affiliated Hospital of Guilin Medical College, Guangxi 541002, China
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| Abstract: |
| ［Abstract］ As a family of endogenous and non-coding small RNAs, microRNAs are known to play a key role in regulating a variety of cellular processes in the post transcription that consist of proliferation,differentiation, apoptosis and immune response. microRNA146a(miR146a) is the first microRNA which was found as the regulator of immunity in mammalian. Concerning its abnormal expression in autoimmune diseases, miR146a has been paid more attention. Understanding the mechanism of miR146a will be helpful to the diagnosis and treatment of autoimmune diseases. In this paper, we review the research advances of miR146a in autoimmune diseases. |
| Key words: Autoimmune diseases microRNA microRNA146a |
