引用本文:周忠向,杨文东.急性脑梗死并发幽门螺旋杆菌感染者血脂水平及氧化应激反应的观察[J].中国临床新医学,2019,12(1):69-72.
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急性脑梗死并发幽门螺旋杆菌感染者血脂水平及氧化应激反应的观察
周忠向,杨文东
257034 山东,胜利石油管理局中心医院心脑血管病研究所(周忠向);257447 山东,利津县第二人民医院检验与病理科(杨文东)
摘要:
[摘要] 目的 通过检测急性脑梗死(ACI)并发幽门螺旋杆菌(Hp)感染者血清血脂、丙二醛(MDA)水平及超氧化物歧化酶(SOD)活性,观察Hp感染对血脂水平及氧化应激反应的影响。方法 选择ACI组200例(Hp感染139例,非Hp感染61例)和健康对照组80名,检测血清Hp-IgG抗体和14C尿素呼气试验(14C-UBT),检测血清血脂、MDA水平及SOD活性。结果 ACI组Hp感染率(69.5%)显著高于对照组(33.8%)(P<0.01)。Hp感染组血清TC、TG、LDL-C显著高于Hp非感染组,而HDL-C水平显著低于Hp非感染组(均P<0.01)。Hp感染组血清MDA水平高于Hp非感染组,而SOD活性低于Hp非感染组,差异有统计学意义(P<0.01)。Hp非感染组血清MDA水平高于对照组,而SOD活性低于对照组,差异有统计学意义(P<0.01)。结论 ACI并发Hp感染者,机体内血脂代谢紊乱加剧及氧化应激反应增强,可能是Hp感染加剧ACI病情的原因之一。
关键词:  急性脑梗死  幽门螺旋杆菌  血脂  氧化应激
DOI:10.3969/j.issn.1674-3806.2019.01.19
分类号:R 743;R 446
基金项目:
Observation of serum lipid level and oxidative stress response in patients with acute cerebral infarction complicated with helicobacter pylori infection
ZHOU Zhong-xiang, YANG Wen-dong
Institute of Cardiovascular and Cerebrovascular Diseases, Shengli Petroleum Administration Center Hospital, Shandong 257034, China
Abstract:
[Abstract] Objective To explore the effect of helicobacter pylori(Hp) infection on blood lipid metabolism and oxidative stress response in patients with acute cerebral infarction(ACI) complicated with Hp infection through the detection of malondialdehyde(MDA) and superoxide dismutase(SOD) activity. Methods Two hundred ACI patients(139 cases of Hp infection and 61 cases of non-infection) were chosen as ACI group and 80 health examinees as control group. The detections of serum Hp-IgG antibody, serum lipid, MDA level and SOD activity, and 14C urea breath test(14C-UBT) were performed. Results The Hp infection rate of the ACI group(69.5%) was significantly higher than that of the control group(33.8%)(P<0.01). In the patients with Hp infection, the levels of TC, TG and LDL-C were significantly higher, and the level of HDL-C was significantly lower than those in the patients without Hp infection(P<0.01). The serum level of MDA was significantly higher and SOD activity was significantly lower in the Hp infection group than those in the Hp non-infection group(P<0.01). The serum level of MDA was significantly higher and SOD activity was significantly lower in the Hp non-infection group than those in the control group(P<0.01). Conclusion Dyslipidemia and oxidative stress reaction are aggravated in the patients with ACI complicated with Hp infection, which may be the cause that aggravates the ACI disease in the patients.
Key words:  Acute cerebral infarction(ACI)  Helicobacter pylori(Hp)  Blood lipid  Oxidative stress