| 摘要: |
| ［摘要］ G蛋白偶联胆汁酸受体（TGR5）是G蛋白偶联受体（GPCR）超家族成员之一，表达于多种组织，如小肠、胃、肝、肺、胎盘以及脾脏等，参与体内多种代谢性疾病的发生。TGR5作为一种代谢调节受体，参与了葡萄糖和血脂代谢，减轻胰岛素抵抗，增加机体能量代谢，也参与调节胆汁酸平衡，并发挥抗炎作用，进而有望成为治疗一系列代谢性疾病的新靶点。该文就TGR5在代谢性疾病中的研究进展进行综述。 |
| 关键词: G蛋白偶联胆汁酸受体 糖代谢 能量代谢 动脉粥样硬化 |
| DOI：10.3969/j.issn.1674-3806.2019.01.28 |
| 分类号:R 58 |
| 基金项目: |
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| Research progress of bile acid receptor TGR5 in metabolic diseases |
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WU Xiao-xian, WANG Xiao-ning
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E-institute of Chinese Traditional Internal Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China
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| Abstract: |
| ［Abstract］ G-protein-coupled bile acid receptor, Gpbar1 (TGR5) is a member of the G-protein-coupled receptor(GPCR) superfamily. TGR5 expresses in various tissues, including the small intestine, stomach, liver, lung, placenta and spleen, and participates in the occurrence of many metabolic diseases in the body. TGR5, as a metabolic regulatory receptor, involves in glucose and lipid metabolism, reducing insulin resistance and increasing the body′s energy metabolism, regulating bile acid balance and keeping the metabolism system in a steady state. This review mainly focuses on the research progress of TGR5 in liver metabolism and its clinical significance in the related liver diseases. |
| Key words: G-protein-coupled bile acid receptor, Gpbar1(TGR5) Glucose metabolism Energy Metabolism Atherosclerosis |
