引用本文:杨 玉,杨海波,韩 璐,丁雪峰.贝那普利联合骨化三醇对糖尿病肾病患者肾功能指标和微炎症因子水平的影响观察[J].中国临床新医学,2019,12(2):154-157.
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贝那普利联合骨化三醇对糖尿病肾病患者肾功能指标和微炎症因子水平的影响观察
杨 玉,杨海波,韩 璐,丁雪峰
132001 吉林,吉化集团公司总医院检验科(杨 玉,韩 璐,丁雪峰),内分泌科(杨海波)
摘要:
[摘要] 目的 观察贝那普利联合骨化三醇治疗早期糖尿病肾病,对患者肾功能指标和微炎症因子水平的影响。方法 将该院收治的96例早期糖尿病肾病患者随机分为对照组和观察组,各48例。对照组采用单纯贝那普利治疗,观察组采用贝那普利联合骨化三醇治疗。对两组患者的血糖指标、肾功能指标、炎症因子水平、治疗效果和不良反应发生情况进行分析比较。结果 两组血糖检测结果和不良反应发生率比较差异均无统计学意义(P>0.05)。观察组肾功能指标和炎症因子水平检测结果均低于对照组,治疗总有效率高于对照组,差异均有统计学意义(P<0.05)。结论 对早期糖尿病肾病患者,采取贝那普利联合骨化三醇治疗,有效改善了患者的肾功能指标,降低了炎症反应,提高了患者的治疗效果。
关键词:  贝那普利  骨化三醇  早期糖尿病肾病  肾功能指标  微炎症因子
DOI:10.3969/j.issn.1674-3806.2019.02.10
分类号:R 446
基金项目:吉林市科技计划项目(编号:201437061)
Effects of benapril combined with calcitriol on renal function indices and microinflammatory factors in diabetic nephropathy patients
YANG Yu, YANG Hai-bo, HAN Lu, et al.
Department of Laboratory Medicine, General Hospital of Jilin Chemical Group Company, Jilin 132001, China
Abstract:
[Abstract] Objective To observe the effects of benapril combined with calcitriol on renal function indices and microinflammatory factors in early diabetic nephropathy patients. Methods Ninty-six early diabetie nephropathy patients were divided into control group and observation group, with 48 cases in each group. The control group was treated with benapril and the observation group was treated with benapril combined with calcitriol. The therapeutic effect, blood glucose, renal function indices, inflammatory factor level and adverse reaction were compared between the two groups. Results There were no significant differences in blood glucose level and adverse reaction rate between the two groups(P>0.05). The renal function indices and inflammatory factor level of the observation group were significantly lower than those of the control group, and the total therapeutic efficiency of the observation group was significantly higher than that of the control group(P<0.05). Conclusion Benapril combined with calcitriol can improve the therapeutic effect of patients with early diabetic nephropathy.
Key words:  Benapril  Calcitriol  Early diabetic nephropathy  Renal function indices  Microinflammatory factors