引用本文:韦利英,李 雪,赵仁峰,刘媛媛,黄伟容,黄晖媛.康复新液对老年患者阴式全子宫切除术后外周血淋巴细胞的影响研究[J].中国临床新医学,2019,12(3):271-275.
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康复新液对老年患者阴式全子宫切除术后外周血淋巴细胞的影响研究
韦利英,李 雪,赵仁峰,刘媛媛,黄伟容,黄晖媛
530021 南宁,广西壮族自治区人民医院妇科
摘要:
[摘要] 目的 探讨康复新液对子宫脱垂行阴式全子宫切除术后老年患者外周血淋巴细胞的影响。方法 选择2014-04~2017-12在广西壮族自治区人民医院妇科因子宫脱垂行经阴道全子宫切除术患者50例作为研究对象,根据患者自愿选择术后是否口服康复新液分为对照组和研究组,每组25例。对照组术后给予抗生素预防感染、卡络磺止血等常规治疗,研究组在常规治疗基础上于术后第2天开始口服康复新液10 ml/次,3次/d,连服14 d。术后第2天(T1)及术后第16天(T2)检测外周血T淋巴细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+)水平,对结果进行比较分析。结果 两组患者T1、T2时点全血CD3+、CD4+、CD8+及CD4+/CD8+ T细胞亚群的比较差异均无统计学意义(P>0.05)。研究组T2时点全血CD4+ T细胞水平高于T1时点,而CD8+ T细胞水平低于T1时点,差异有统计学意义(P<0.05);CD3+及CD4+/CD8+ T细胞的改变差异无统计学意义(P>0.05)。对照组T1时点与T2时点相比较,患者全血CD3+、CD4+、CD8+ T细胞水平及CD4+/CD8+ T细胞水平的比较差异均无统计学意义(P>0.05)。结论 子宫脱垂经阴道子宫切除术后辅助口服康复新液治疗可能更好地调节老年患者细胞免疫功能,利于术后康复,但有待大样本、高质量的临床研究进一步验证。
关键词:  康复新液  老年患者  阴式全子宫切除术  免疫功能
DOI:10.3969/j.issn.1674-3806.2019.03.08
分类号:R 713
基金项目:广西卫健委中医药科技专项课题(编号:GZLC14-33)
Study on the effect of Kangfuxin Liquid on cellular immunity in elderly patients receiving vaginal hysterectomy
WEI Li-ying, LI Xue, ZHAO Ren-feng, et al.
Department of Gynecology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
Abstract:
[Abstract] Objective To explore the effect of Kangfuxin Liquid on cellular immunity in elderly patients with uterine prolapse receiving vaginal hysterectomy. Methods Fifty elderly patients with uterine prolapse who received vaginal hysterectomy in the Department of Gynecology of the People′s Hospital of Guangxi Zhuang Autonomous Region during April 2014 and December 2017 were divided into study group and control group depending on whether voluntary oral admimistration of Kangfuxin Liquid was selected after surgery, with 25 cases in each group. The control group was given routine treatment such as antibiotics to prevent infections and carbazochrome to stop bleeding after vaginal hysterectomy, while the study group received the same treatment as the control group plus Kangfuxin Liquid on the second day after operation(10 ml per time, 3 times daily for 14 days). The changes in peripheral T-lymphocyte subsets(CD3+, CD4+, CD8+, CD4+/CD8+) were detected on day 2 after surgery(T1) and day 16 after surgery(T2), and the results were compared between the two groups. Results There were no significant differences in the blood levels of CD3+, CD4+, CD8+ and CD4+/CD8+ T-lymphocyte subsets on day 2 after surgery(T1) and day 16 after surgery(T2) between the two groups(P>0.05). In the the study group, the blood level of CD4+ T cell on day 16 after surgery(T2) was significantly higher than that on day 2 after surgery(T1), while the serum level of CD8+ T cell was significantly lower than that on day 2 after surgery(T1) (P<0.05); there were no significant differences in the changes of CD3+ T cell and CD4+/CD8+ T cell(P>0.05). In the control group, there were no significant differences in the blood levels of CD3+, CD4+, CD8+ and CD4+/CD8+ T cells between T1 and T2(P>0.05). Conclusion Adjuvant oral Kangfuxin Liquid therapy may better regulate cellular immune function in the elderly patiens with uterine prolapse who received vaginal hysterectomy. It is beneficial for the postoperative rehabilitation, however, it needs to be further verified by large sample and high-quality clinical researches.
Key words:  Kangfuxin Liquid  Elderly patients  Vaginal hysterectomy  Immune function