引用本文:宋志强,郑 岩,罗 蕊.复方黄柏液防治鼻咽癌放射治疗所致口腔黏膜炎的效果观察[J].中国临床新医学,2019,12(4):433-435.
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复方黄柏液防治鼻咽癌放射治疗所致口腔黏膜炎的效果观察
宋志强,郑 岩,罗 蕊
028000 内蒙古,通辽市医院耳鼻喉科
摘要:
[摘要] 目的 观察复方黄柏液对鼻咽癌患者放射治疗所致口腔黏膜炎的防治效果。方法 采用平行、随机对照的研究方法,将83例鼻咽癌患者随机分为观察组(42例)和对照组(41例),观察组在放射治疗开始时应用复方黄柏液,对照组应用复方氯己定含漱液。采用CTCAE v3.0口腔黏膜炎分级标准和口述分级评分法(VRS)疼痛分级标准,评价两组患者在临床试验结束时口腔黏膜炎和口腔疼痛的发生程度。结果 观察组放射治疗后口腔黏膜炎的发生程度明显低于对照组,差异有统计学意义(P<0.05);观察组放射治疗后口腔疼痛程度明显低于对照组,差异有统计学意义(P<0.05)。结论 复方黄柏液可防治鼻咽癌放射治疗所致口腔黏膜炎和口腔疼痛,值得临床推广应用。
关键词:  复方黄柏液  鼻咽癌  放射治疗  口腔  黏膜炎  疼痛
DOI:10.3969/j.issn.1674-3806.2019.04.21
分类号:R 856.76
基金项目:
Effect of compound phellodendron gargle on radiotherapy-induced oral mucositis in nasopharyngeal carcinoma patients
SONG Zhi-qiang, ZHENG Yan, LUO Rui
Department of Otolaryngology, Tongliao City Hospital, Inner Mongolia Autonomous Region 028000, China
Abstract:
[Abstract] Objective To observe the effect of compound phellodendron gargle on radiotherapy-induced oral mucositis in nasopharyngeal carcinoma patients. Methods A total of 83 nasopharyngeal carcinoma patients were randomly divided into observation group and control group. The observation group(n=42) was treated with radiotherapy plus compound phellodendron oral gargle, while the control group(n=41) was treated with radiotherapy plus compound chlorhexidine gargle. The incidence of oral mucositis was evaluated by Common Terminology Criteria for Adverse Events(CTCAE) v3.0 and the incidence of oral pain was evaluated by Verbal Rating Scale(VRS) in the two groups at the end of the clinical trial. Results Compared with that in the control group, the incidence of oral mucositis in the observation group was significantly decreased(P<0.05). The degree of oral pain in the observation group was lower than that in the control group(P<0.05). Conclusion Compound phellodendron gargle can attenuate the radiotherapy-induced oral mucositis and oral pain in nasopharyngeal carcinoma patients.
Key words:  Compound phellodendron gargle  Nasopharyngeal carcinoma  Radiotherapy  Oral cavity  Mucositis  Pain