引用本文:杨弘文,汤春琼,区嘉欢,刘丽芳,李趣红.25(OH)D水平与老年脑梗死患者认知功能障碍的关系探讨[J].中国临床新医学,2019,12(6):608-611.
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25(OH)D水平与老年脑梗死患者认知功能障碍的关系探讨
杨弘文,汤春琼,区嘉欢,刘丽芳,李趣红
528224 广东,南方医科大学南海医院神经内科
摘要:
[摘要] 目的 探讨血清25羟基维生素D[25(OH)D]水平与老年患者脑梗死后认知功能障碍(PSCI)的关系。方法 选取2015-01~2017-12该院年龄>60岁的老年脑梗死患者368例作为研究对象,患者根据蒙特利尔认知评估量表(MoCA)分为非脑梗死后认知功能障碍(NPSCI)组253例和PSCI组115例。另选择健康体检老年人30名作为正常对照组。比较三组患者血清25(OH)D水平,并用Logistic回归分析PSCI发生的危险因素。结果 NPSCI组和PSCI组血清25(OH)D水平均低于正常对照组(P<0.05)。PSCI组血清25(OH)D水平低于NPSCI组(P<0.05)。Logistic回归分析结果显示,低血清25(OH)D水平、较大的年龄、男性、高血压史、糖尿病史和中风史是PSCI发生的独立危险因素。结论 血清25(OH)D缺乏与PSCI的发生具有关联,低血清25(OH)D水平可能是老年患者PSCI发生的独立危险因素。
关键词:  25羟基维生素D  脑梗死  认知功能  危险因素
DOI:10.3969/j.issn.1674-3806.2019.06.07
分类号:R 743.3
基金项目:国家自然科学基金资助项目(编号:81873753)
Relationship between 25(OH)D levels and cognitive impairment in elderly patients with cerebral infarction
YANG Hong-wen, TANG Chun-qiong, OU Jia-huan, et al.
Department of Neurology, Nanhai Hospital of Southern Medical University, Guangdong 528224, China
Abstract:
[Abstract] Objective To explore the relationship between serum 25-hydroxy vitmin D[25(OH)D] levels and the occurrence of poststroke cognitive impairment(PSCI) in elderly patients. Methods Three hundred and sixty-eight elderly cerebral infarction patients who were over 60 years old were selected in our hospital from January 2015 to December 2017, and were divided into non-poststroke cognitive impairment(NPSCI) group(n=253) and PSCI group(n=115) according to the Montreal Cognitive Assessment Scale(MoCA). Thirty elderly people from physical examination were selected as normal control group. The levels of serum 25(OH)D were compared among the three groups, and the risk factors of PSCI were analyzed by Logistic regression analysis. Results The serum 25(OH)D levels in both the PSCI group and the NPSCI group were significantly lower than those in the normal control group(P<0.05). In addition, the PSCI group had lower levels of serum 25(OH)D compared to the NPSCI group(P<0.05). Logistic regression analysis results showed that lower serum 25(OH)D level, old age, male, history of hypertension, history of diabetes, and history of strok were the independent risk factors of PSCI. Conclusion Serum 25(OH)D level is associated with the occurrence of PSCI. Low serum 25(OH)D level may be an independent risk factor for PSCI in elderly patients.
Key words:  25-hydroxy vitamin D[25(OH)D]  Cerebral infarction  Cognitive function  Risk factors