| 摘要: |
| ［摘要］ 目的 探讨不同临床病理学参数口腔舌鳞癌神经周浸润(PNI)的特点及其意义。方法 观察29例不同肿瘤分化程度、T分期及淋巴结转移的口腔舌鳞状细胞癌PNI的特点，分析不同临床参数与PNI的关系。结果 舌鳞癌组织中神经束数量与正常组织比较差异无统计学意义(P>0.05)；中、低分化鳞癌患者PNI阳性率高于高分化鳞癌患者，差异有统计学意义(P<0.05)；不同临床T分期患者PNI阳性率比较差异无统计学意义(P>0.05)；淋巴结转移鳞癌患者PNI阳性率高于无淋巴结转移鳞癌患者，差异有统计学意义(P<0.05)。结论 舌鳞癌组织中未见新生的神经束，中低分化口腔舌鳞癌嗜神经性高于高分化鳞癌，伴淋巴结转移的口腔舌鳞癌嗜神经性高于无淋巴结转移口腔舌鳞癌。 |
| 关键词: 口腔鳞状细胞癌 神经周浸润 神经束 肿瘤转移 |
| DOI：10.3969/j.issn.1674-3806.2019.06.08 |
| 分类号:R 780.2 |
| 基金项目:广西自然科学基金重点项目（编号：2016GXNSFDA380002） |
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| Characteristics and significances of perineural invasion in oral tongue squamous carcinoma with different clinical and pathological parameters |
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LI Rou-xi, WU Man-man, CHEN Jun-wen, et al.
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College of Stomatology, Guangxi Medical University, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, Guangxi Key Laboratory for the Diagnosis and Treatment of Maxillofacial Surgical Diseases(Guangxi Key University Laboratory), Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To explore the characteristics and significances of perineural invasion(PNI) in oral tongue squamous carcinoma with different clinical pathological parameters. Methods The PNI characteristics of 29 oral tongue squamous cell carcinoma patients with different tumor differentiations, T stages and lymph node metastasis were observed, and the relationship between different clinical parameters and PNI was analyzed. Results There was no significant difference between the number of nerve bundles in the normal tissue and the tongue squamous carcinoma tissue(P>0.05). The PNI rate was significantly higher in the moderately and poorly differentiated squamous cell carcinoma than that in the well-differentiated squamous cell carcinoma(P<0.05). There was no significant difference in PNI rate among the patients at different T stages(P>0.05). The PNI rate of the patients with lymphatic metastatic squamous cell carcinoma was significantly higher than that of the patients with no lymphatic metastatic squamous cell carcinoma(P<0.05). Conclusion No regenerative nerve bundles are found in the tongue squamous cell carcinoma tissues. The neurotrophic properties of the moderately and poorly differentiated oral tongue squamous cell carcinoma are higher than those of the well-differentiated squamous cell carcinoma, and the neurotrophic properties of the oral tongue squamous cell carcinoma with lymph nodemetasis are higher than those without lymph node metastasis. |
| Key words: Oral squamous cell carcinoma Perineural invasion Nerve bundle Tumor metastasis |
