引用本文:李新叶,代 艳,陆元奉,陆春久,石丰浪,罗裕有,凌光满,刘兴夏.儿童紫癜性肾炎的危险因素研究[J].中国临床新医学,2019,12(6):630-633.
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儿童紫癜性肾炎的危险因素研究
李新叶,代 艳,陆元奉,陆春久,石丰浪,罗裕有,凌光满,刘兴夏
530021 南宁,广西壮族自治区人民医院儿科
摘要:
[摘要] 目的 探讨儿童紫癜性肾炎(HSPN)的危险因素。方法 收集2013-01-01~2017-12-31该院住院的过敏性紫癜(HSP)106例患儿的临床资料和相关实验室检查结果。将这些患儿分为HSPN组和非紫癜性肾炎(HSPWN)组,采用病例对照研究设计方案比较两组患儿的HSPN相关暴露因素。结果 106例患儿中男66例,女40例,中位年龄7岁。根据2009年中华医学会儿科学会肾脏病学组制定并发布的《紫癜性肾炎的诊治循证指南(试行)》中的HSPN诊断标准分为HSPN组39例和HSPWN组67例。HSPN发生率为36.79%,其中男24例,女15例;中位年龄9.50岁。HSPN组总胆固醇、肌酐、尿酸、胱抑素C水平显著高于HSPWN组(P<0.05),而内生肌酐清除率(Ccr)显著低于HSPWN组(P<0.05)。多因素Logistic回归分析发现总胆固醇是HSPN的危险因素(OR=1.558,P=0.014)。结论 总胆固醇水平升高是儿童HSPN的危险因素。
关键词:  儿童  过敏性紫癜  紫癜性肾炎  危险因素  总胆固醇  胱抑素C
DOI:10.3969/j.issn.1674-3806.2019.06.13
分类号:R 725
基金项目:广西卫健委科研课题(编号:Z2010229)
Study on risk factors of Henoch-Schönlein purpura nephritis in children
LI Xin-ye, DAI Yan, LU Yuan-feng, et al.
Department of Pediatrics, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
Abstract:
[Abstract] Objective To investigate the risk factors of Henoch-Schönlein purpura nephritis(HSPN) in children. Methods The clinical data and related laboratory test results of 106 children with Henoch-Schönlein purpura(HSP) who were hospitalized in our department from January 1 2013 to December 31 2017 were collectded and analyzed. These patients were divided into HSPN group and HSP without nephritis(HSPWN) group, and case-control study design was used to compare the relevant exposure factors between the two groups. Results A total of 106 patients were enrolled, among whom there were 66 males and 40 females with a median age of 7 years. These patients were divided into the HSPN group(n=39) and the HSPWN group(n=67) according to the HSPN diagnostic criteria in the Guidelines for the Diagnosis and Treatment of Purpura Nephritis(Trial) which was formulated and released by the Nephrology Group of the Pediatrics Society of the Chinese Medical Association in 2009. The incidence of HSPN was 36.79% in the HSP patients, including 24 males and 15 females, with median age being 9.50 years. The levels of total cholesterol, creatinine, uric acid, and cystatin C in the children with HSPN were significantly higher than those in the children with HSPWN(P<0.05), while the level of creatinine clearance rate(Ccr) in the HSPN group was significantly lower than that in the HSPWN group(P<0.05). Logistic multivariate regression analysis showed that the elevated level of total cholesterol was the risk factor of HSPN(OR=1.558, P=0.014). Conclusion The elevated level of total cholesterol is the risk factors for children with HSPN.
Key words:  Children  Henoch-Schnlein purpura(HSP)  Henoch-Schnlein purpura nephritis(HSPN)  Risk factors  Total cholesterol  Cystatin C