| 摘要: |
| ［摘要］ 目的 探讨直肠癌术前中性粒细胞与淋巴细胞比值（neutrophil-to-lymphocyte ratio，NLR）、淋巴细胞与单核细胞比值（lymphocyte-to-monocyte ratio，LMR）与术后病理结果脉管癌栓之间的关系。方法 回顾性分析2014-01～2017-12郑州大学第二附属医院普外科初诊入院并行手术根治的321例直肠癌患者术前血常规及临床病理资料，根据患者术后病理资料将其分为有脉管癌栓组84例和无脉管癌栓组237例，分析脉管癌栓与术前NLR、LMR及临床病理资料之间关系。结果 单因素分析中T分期、N分期、分化程度、术前NLR及LMR与直肠癌脉管癌栓差异有统计学意义（P均<0.05），多因素分析结果显示N分期中N1+N2、术前高NLR及术前低LMR为其独立危险因素（P均<0.05）。结论 术前NLR、LMR的高低，可协助术者判断直肠癌患者有无脉管癌栓，为肿瘤分期提供帮助，术前高NLR及低LMR提示直肠癌脉管癌栓可能性大。 |
| 关键词: 直肠癌 脉管癌栓 中性粒细胞与淋巴细胞比值 淋巴细胞与单核细胞比值 |
| DOI：10.3969/j.issn.1674-3806.2019.06.18 |
| 分类号:R 269 |
| 基金项目: |
|
| Relationship between vascular tumor thrombus of rectal cancer and preoperative NLR and LMR |
|
KANG Qi, NIU Yue-ping, GAO Jian, et al.
|
|
The Second Clinical College of Zhengzhou University, Henan 450000, China
|
| Abstract: |
| ［Abstract］ Objective To investigate the relationship between preoperative neutrophil-to-lymphocyte ratio(NLR), lymphocyte-to-monocyte ratio(LMR) and postoperative pathological findings of vascular tumor thrombi in rectal cancer patients. Methods A retrospective analysis of the preoperative blood test and clinicopathological data of 321 patients with rectal cancer who were initially admitted to the Department of General Surgery of the Second Affiliated Hospital of Zhengzhou University and underwent radical surgery from January 2014 to December 2017 was performed. According to the postoperative pathological data, the patients were divided into lymphovascular invasion group(n=84) and non-lymphovascular invasion group(n=237). The correlation between vascular tumor thrombus and preoperative NLR, LMR and clinical pathological data was analyzed. Results The results of univariate analysis showed that T stage, N stage, differentiation degree, preoperative NLR and LMR were significantly correlated with rectal cancer vascular tumor thrombi(P<0.05). Multivariate analysis showed that N1+N2 in N stage, preoperative high NLR and low LMR were the independent risk factors for lymphovascular invasion in the patients with rectal cancer(P<0.05). Conclusion The levels of preoperative NLR and LMR can help the surgeons to determine whether there is lymphovascular invasion in rectal cancer patients, and help to determine the tumor stages before surgery. Preoperative high NLR and low LMR suggest an increased chance of lymphovascular invasion in rectal cancer patients. |
| Key words: Rectal cancer Vascular tumor thrombus Neutrophil-to-lymphocyte ratio(NLR) Lymphocyte-to-monocyte ratio(LMR) |
