| 摘要: |
| ［摘要］ 目的 探讨法洛四联症（TOF）患者血浆脑利钠肽（BNP）与右室功能的相关性。方法 选择2016-02～2017-06该院收治的TOF患者共30例作为研究组，另选取同期无症状室间隔缺损患者30例作为对照组。两组患者均进行手术治疗。记录两组受试者在术前、术后1周、术后1个月及术后3个月的血浆BNP水平，以及研究组病例术前、术后右室舒张末期容积（RVEDV）、右心室前壁厚度（RVAW）、右心室舒张早期与舒张晚期峰值血流充盈速度比值（E/A）、左心室射血分数（LVEF）、右心射血等容时间指数（Tei-index）等指标。结果 研究组术前、术后1周、术后1个月及术后3个月的BNP水平均显著高于同时点的对照组（P<0.05）。从术前到术后1周、术后1个月、术后3个月，研究组患者BNP、RVEDV、RVAW、E/A、LVEF、Tei-index均逐渐下降，差异有统计学意义（P<0.05）。Pearson相关性分析结果显示，研究组术后1周、术后1个月、术后3个月BNP水平与患者RVEDV、RVAW、E/A、Tei-index均呈正相关（P<0.05）。结论 TOF患者血浆BNP水平明显较高，且患者BNP水平与右心功能密切相关。 |
| 关键词: 法洛四联症 血浆脑利钠肽 右心功能 |
| DOI：10.3969/j.issn.1674-3806.2019.07.13 |
| 分类号:R 541.1 |
| 基金项目:广西卫健委科研课题（编号：Z2012681） |
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| Correlation of plasma brain natriuretic peptide and right ventricular function in patients with tetralogy of Fallot |
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LING Yi, DENG Hai-qing
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Department of Cardiothoracic Surgery, the Second People′s Hospital of Qinzhou City, Guangxi 535000, China
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| Abstract: |
| ［Abstract］ Objective To investigate the correlation of plasma brain natriuretic peptide(BNP) and the right ventricular function in patients with tetralogy of Fallot(TOF). Methods From February 2016 to June 2017, 30 patients with TOF in our hospital were enrolled as the reseach group, and other 30 patients with asymptomatic ventricular septal defect were enrolled as the control group. Both of the two groups underwent surgery. The plasma BNP were recorded in the two groups before operation and 1 week, 1 month and 3 months after operation. The right ventricular end-diastolic volume(RVEDV), right ventricular anterior wall thickness(RVAW), ratio of peak blood flow filling velocity in early and late diastolic period of right ventricle(E/A), left ventricular ejection fraction(LVEF) and Tei-index in the reseach group were recorded before and after operation. Results The levels of plasma BNP in the reseach group were significantly higher than those in the control group before operation and 1 week, 1 month and 3 months after operation（P<0.05）. In the reseach group, the levels of BNP, RVEDV, RVAW, E/A, LVEF and Tei-index were gradually decreased with the time going from preoperation to 1 week, 1 month and 3 months after operation（P<0.05）. The results of Pearson correlation analysis showed that the levels of BNP were significantly positively correlated with the levels of RVEDV, RVAW, E/A and Tei-index at 1 week, 1 month and 3 months after operation（P<0.05）. Conclusion The level of plasma BNP is obviously higher in the patients with TOF, and the BNP level is closely related to the right ventricular function. |
| Key words: Tetralogy of Fallot(TOF) Plasma brain natriuretic peptide(BNP) Right ventricular function |
