| 摘要: |
| ［摘要］ 目的 观察脾氨肽治疗小儿难治性肺炎支原体肺炎的临床疗效及对免疫影响。方法 选取郑州儿童医院2016-01～2018-01收治的48例难治性肺炎支原体肺炎患儿作为研究对象，随机分为两组，每组24例。对照组给予大环内酯类药物联合糖皮质激素治疗。观察组在对照组的基础上，给予脾氨肽治疗。总疗程均为1个月。比较两组患儿临床疗效及治疗前及治疗1个月后血清白细胞介素-2（IL-2）、白细胞介素-6（IL-6）、白细胞介素-10（IL-10）水平变化情况。结果 观察组患儿临床疗效显著，住院时间、发热消失时间、咳嗽消失时间、肺部啰音消失时间及胸部X线阴影消失时间较对照组均显著缩短（P<0.05）。观察组血清IL-6水平较对照组显著下降，而IL-2水平较对照组显著升高，差异均有统计学意义（P<0.05）。结论 脾氨肽能够通过调节难治性肺炎支原体肺炎患儿血清IL-2、IL-6水平来调节机体的免疫状态，促进临床症状及体征的改善。 |
| 关键词: 脾氨肽 难治性肺炎支原体肺炎 白细胞介素-2 白细胞介素-6 白细胞介素-10 |
| DOI：10.3969/j.issn.1674-3806.2019.07.14 |
| 分类号:R 725.6 |
| 基金项目: |
|
| Curative and immune effects of spleen aminopeptide on refractory mycoplasma pneumoniae pneumonia in children |
|
GAO Jun-fang, ZHANG Guang-chao, SUN Xiao-min
|
|
The First Department of General Internal Medicine, the Children′s Hospital of Zhengzhou, Henan 450000, China
|
| Abstract: |
| ［Abstract］ Objective To observe the curative and immune effects of spleen aminopeptide on refractory mycoplasma pneumoniae pneumonia(RMPP) in children. Methods Forty-eight children diagnosed with RMPP in the Children′s Hospital of Zhengzhou between January 2016 and January 2018 were collected as the research subjects and were randomly divided into two groups, with 24 cases in each group. The control group was treated with macrolides combined with glucocorticoid and the observation group was treated with spleen aminopeptide plus the same treatment as the control group. The total course of treatment was 1 month in both of the two groups. The clinical effects and the changes of the levels of serum interleukin-2(IL-2), interleukin-6(IL-6) and interleukin-10(IL-10) were compared between the two groups. Results After treatment, the curative effect of the observation group was significant. The hospitalization time, and the disappearance time of fever, cough and lung rale and chest X-ray shadow in the observation group was significantly shorter than that in the control group(P<0.05). The level of serum IL-6 in the observation group was significantly lower than that in the control group(P<0.05), and the level of IL-2 in the observation group was significantly higher than that in the control group(P<0.05). Conclusion Spleen aminopeptide can regulate the immune status of the body and promote the recovery of clinical symptoms and signs by regulating the serum levels of IL-2, IL-6 and IL-10 in RMPP children. |
| Key words: Spleen aminopeptide Refractory mycoplasma pneumoniae pneumonia(RMPP) Interleukin-2(IL-2) Interleukin-6(IL-6) Interleukin-10(IL-10) |
