| 摘要: |
| ［摘要］ 降钙素基因相关肽（calcitonin gene-related peptide，CGRP）是一种可强烈舒张血管的感觉神经肽，具有减轻心肌缺血/再灌注损伤（myocardial ischemia/reperfusion injury，MI/RI）的作用，但其具体机制仍不清楚。心肌三磷酸腺苷（ATP）敏感性钾通道（KATP）具有联系细胞新陈代谢与细胞膜的兴奋性的作用，涉及对心率失常及心衰的保护。而KATP可能是CGRP减轻MI/RI作用通路中的关键节点。该文就KATP在CGRP心肌保护中的作用作一综述，阐述CGRP减轻MI/RI的作用机制。 |
| 关键词: 降钙素基因相关肽 心肌三磷酸腺苷敏感性钾通道 缺血/再灌注损伤 心肌 |
| DOI：10.3969/j.issn.1674-3806.2019.07.29 |
| 分类号:R 614 |
| 基金项目: |
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| Advances in research on the role of ATP-sensitive potassium channel in cardioprotection of calcitonin gene-related peptide |
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WANG Chen, YUAN Da-jiang
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Shanxi Medical University, Taiyuan 030001, China
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| Abstract: |
| ［Abstract］ Calcitonin gene-related peptide(CGRP) is a kind of sensory neuropeptide that can strongly vasodilate blood vessels and has the effects of reducing myocardial ischemia/reperfusion injury(MI / RI), but the exact mechanism is still unknown. Myocardial ATP-sensitive potassium channels(KATP) have the effect of associating cell metabolism with the excitability of the cell membrane and involve the protection of arrhythmias and heart failure. Moreover, KATP channel may be a key node in the pathway of CGRP to reduce MI/RI. This paper aims at stating the role of KATP in myocardial protection of CGRP, and the mechanism of CGRP in reducing MI/RI is further described. |
| Key words: Calcitonin gene-related peptide（CGRP） ATP-sensitive potassium channels(KATP) Ischemia/reperfusion injury(I/RI) Myocardium |
