引用本文:张 玲,张 业,张 雪,朱亚萍,马 麒,白飞虎.幽门螺杆菌感染情况与胆囊结石 胆囊炎和胆囊息肉的关联性分析[J].中国临床新医学,2019,12(11):1185-1188.
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幽门螺杆菌感染情况与胆囊结石 胆囊炎和胆囊息肉的关联性分析
张 玲,张 业,张 雪,朱亚萍,马 麒,白飞虎
750021 银川,西北民族大学第一附属医院消化内科(张 玲,张 雪,朱亚萍,马 麒);475000 开封,河南大学第一附属医院普外科(张 业);750021 银川,宁夏回族自治区人民医院消化内科(白飞虎)
摘要:
[摘要] 目的 分析幽门螺杆菌(Hp)感染与胆囊结石、胆囊炎和胆囊息肉的关联性,探讨根除Hp在预防胆囊疾病的临床价值。方法 回顾性收集2018-06~2018-12在该院以腹部不适症状就诊并行Hp尿素酶抗体检测的临床病例资料962例。分析胆囊炎、胆囊结石、胆囊息肉的发生与Hp感染的关联性,以及不同Hp感染情况下相关胆囊疾病的临床特征。结果 Hp阳性组433例,Hp阴性组529例,Hp感染率为45.01%(433/962)。Hp阳性组的平均年龄、患胆囊结石及胆囊炎的人数比例大于Hp阴性组,差异有统计学意义(P<0.05)。在胆囊结石患者中,Hp阳性者的总胆固醇水平高于Hp阴性者,差异有统计学意义(P<0.05)。在胆囊炎患者中,Hp阳性者平均白细胞计数水平高于Hp阴性者,差异有统计学意义(P<0.05)。结论 Hp感染可能与胆囊炎、胆囊结石的发生、发展存在一定的关联性。
关键词:  幽门螺杆菌  胆囊炎  胆囊结石  胆囊息肉
DOI:10.3969/j.issn.1674-3806.2019.11.09
分类号:R 575
基金项目:宁夏消化疾病临床医学研究中心课题(编号:2018CXPT0075)
The relationship between helicobacter pylori infection and cholecystolithiasis, cholecystitis and gallbladder polyps
ZHANG Ling, ZHANG Ye, ZHANG Xue, et al.
Department of Gastroenterology, the First Affiliated Hospital of Northwest University for Nationalities, Yinchuan 750021, China
Abstract:
[Abstract] Objective To study the relationship between helicobacter pylori(Hp) infection and cholecystolithiasis, cholecystitis and gallbladder polyps, and to explore the clinical value of Hp eradication in prevention of gallbladder diseases. Methods Nine hundred and sixty-two cases with abdominal discomfort and detection of Hp urease antibody were collected in our hospital from June 2018 to December 2018 and their clinical data were retrospectively analyzed. The relationship between the occurrence of cholecystitis, cholecystolithiasis and gallbladder polyps and Hp infection, and the clinical characteristics of gallbladder diseases under different Hp infections were analyzed. Results In this study, there were 433 cases in the Hp positive group and 529 cases in the Hp negative group, and the Hp infection rate was 45.01%(433/962). The average age of the patients and the proportion of the patients with cholecystolithiasis and cholecystitis in the Hp positive group were significantly larger than those in the Hp negative group(P<0.05). In the patients with cholecystolithiasis, the total cholesterol level of the Hp positive patients was significantly higher than that of the Hp negative patients(P<0.05). In the patients with cholecystitis, the average white blood cell count of the Hp positive patients was significantly higher than that of the Hp negative patients(P<0.05). Conclusion Hp infection may be associated with the occurrence and development of cholecystitis and cholecystolithiasis.
Key words:  Helicobacter pylori(Hp)  Cholecystitis  Cholecystolithiasis  Gallbladder polyps