引用本文:蒙丹丽,梁列新,宋怀宇.乙肝相关慢加急性肝衰竭患者粪便胆汁酸谱变化的研究[J].中国临床新医学,2019,12(11):1188-1192.
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乙肝相关慢加急性肝衰竭患者粪便胆汁酸谱变化的研究
蒙丹丽,梁列新,宋怀宇
530021 南宁,广西壮族自治区人民医院消化内科
摘要:
[摘要] 目的 检测乙肝相关慢加急性肝衰竭患者粪便胆汁酸谱水平,了解其在疾病发展中的意义。方法 选取20例乙肝相关慢加急性肝衰竭患者为观察组,随机选取14名体检健康者作为对照组。应用高效液相色谱(HPLC)法检测两组粪便胆汁酸(胆酸、石胆酸、脱氧胆酸、鹅脱氧胆酸、熊脱氧胆酸及总胆汁酸)的水平。结果 观察组粪便胆酸水平高于对照组(P<0.05),石胆酸、脱氧胆酸、鹅脱氧胆酸、熊脱氧胆酸及总胆汁酸水平与对照组相比差异无统计学意义(P>0.05)。伴/不伴肝性脑病两组患者,伴/不伴腹水两组患者,Child-Pugh B级与C级两组患者胆汁酸水平差异无统计学意义(P>0.05)。结论 乙肝相关慢加急性肝衰竭患者粪便胆酸水平较正常人升高,但总胆汁酸和其他胆汁酸水平与正常人相比无显著差异。
关键词:  乙肝相关慢加急性肝衰竭  胆汁酸  高效液相色谱
DOI:10.3969/j.issn.1674-3806.2019.11.10
分类号:R 57
基金项目:广西医疗卫生适宜技术研究与开发项目(编号:S201313-04);广西卫健委科研课题(编号:Z2004002)
A research on the changes of fecal bile acid spectrum in patients with hepatitis-B-related acute-on-chronic liver failure
MENG Dan-li, LIANG Lie-xin, SONG Huai-yu
Department of Gastroenterology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
Abstract:
[Abstract] Objective To detect the levels of fecal bile acid spectrum in patients with hepatitis-B-related acute-on-chronic liver failure(ACLF), and to understand its significance in the development of the disease. Methods Twenty patients diagnosed with ACLF were selected as the observation group, and fourteen healthy individuals were randomly selected as the control group. The levels of fecal bile acid(cholic acid, lithocholic acid, deoxycholic acid,chenodeoxycholic acid,ursodeoxycholic acid and total bile acid) were detected by high performance liquid chromatography(HPLC). Results The level of fecal cholic acid in the observation group was significantly higher than that in the control group(P<0.05). There were no significant differences in the levels of lithocholic acid, deoxycholic acid, chenodeoxycholic acid, ursodeoxycholic acid and total bile acid between the observation group and the control group(P>0.05). There were no significant differences in the levels of bile acid between the patients with hepatic encephalopathy and those without hepatic encephalopathy(P>0.05). There were no significant differences in the levels of bile acid between the patients with ascites and those without ascites(P>0.05). There were no significant differences in the levels of bile acid between the patients with Child-Pugh B and those with Child-Pugh C patients(P>0.05). Conclusion The levels of fecal cholic acid of ACLF patients are higher than those of healthy individuals, but there are no significant differences in total bile acid and other bile acids between ACLF patients and healthy individuals.
Key words:  Hepatitis-B-related acute-on-chronic liver failure(ACLF)  Bile acid  High performance liquid chromatography(HPLC)