引用本文:史学凯,农常亮,何 潇,吴 华,曾贵祥,潘新年.振幅整合脑电图在早产儿脑损伤中的诊断价值[J].中国临床新医学,2019,12(11):1203-1205.
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振幅整合脑电图在早产儿脑损伤中的诊断价值
史学凯,农常亮,何 潇,吴 华,曾贵祥,潘新年
530031 广西,南宁市第二人民医院新生儿科(史学凯,农常亮,何 潇,吴 华);530028 广西,南宁市妇幼保健院新生儿科(曾贵祥);530027 南宁,广西壮族自治区妇幼保健院新生儿科(潘新年)
摘要:
[摘要] 目的 评估振幅整合脑电图(aEEG)对早产儿脑损伤的早期诊断价值。方法 选择存在脑损伤高危因素的早产儿91例,根据床旁彩色B超及神经系统症状分为脑损伤组(47例)和非脑损伤组(44例),于出生后6 h内行aEEG描记,出生后10~14 d行头颅MRI检查,纠正胎龄3个月行中国儿童发展中心(CDCC)婴儿智能发育量表评分,根据aEEG背景活动、振幅及睡眠觉醒周期(SWC)来判读其异常程度,具体分类为正常、轻度异常及重度异常,分析aEEG不同的表现分类与CDCC评分及MRI的关系。结果 aEEG轻度异常组45例,其MRI检查阳性率为37.78%,其纠正胎龄3个月的CDCC的运动发育指数(PDI)评分为(92.5±10.6)分,智能发育指数(MDI)评分为(95.7±12.4)分;重度异常组19例,MRI检查阳性率为73.68%,PDI评分为(66.3±17.4)分,MDI评分为(67.2±15.1)分,两组在MRI检查阳性率PDI评分及MDI评分方面比较差异有统计学意义(P<0.05)。结论 aEEG对早产儿脑损伤有诊断价值,尽早干预可减轻脑损伤,值得推广及应用。
关键词:  早产儿  振幅整合脑电图  脑损伤  婴儿智能发育量表
DOI:10.3969/j.issn.1674-3806.2019.11.14
分类号:R 712.6
基金项目:南宁市科学研究与技术开发计划项目(编号:20173017-4)
Diagnostic value of amplitude integrated electroencephalogram in brain injury of premature infants
SHI Xue-kai, NONG Chang-liang, HE Xiao, et al.
Department of Neonatology, the Second Nanning People′s Hospital, Guangxi 530031, China
Abstract:
[Abstract] Objective To evaluate the early predictive value of amplitude integrated electroencephalogram(aEEG) for brain injury in premature infants. Methods  Ninety-one preterm infants with high risk factors of brain injury were divided into the brain injury group(n=47) and the non-brain injury group(n=44) according to bedside color B-ultrasound and neurological symptoms. aEEG was performed within 6 hours after birth, and magnetic resonance imaging(MRI) was performed 10~14 days after birth. Children′s Development Center of China(CDCC) infant intelligence development scale examination was performed after 3 months of corrected gestational age. According to the background activity, amplitude and sleep wake cycle(SWC) of aEEG, the abnormal degrees of aEEG which were classified as normal degree, mildly abnormal degree and severely abnormal degree were judged. The relationships between the different classifications of aEEG and CDCC scale and MRI were analyzed. Results In the mildly abnormal aEEG group(45 cases), the MRI positive rate was 37.78%; the psychomotor development index(PDI) scores of CDCC corrected for 3 months were (92.5±10.6)points, and the mental development index(MDI) scores were (95.7±12.4)points. In the severely abnormal aEEG group(19 cases), the MRI positive rate was 73.68%; the PDI scores were (66.3±17.4)points, and the MDI scores were (67.2±15.1)points. There were significant differences in MRI positive rates, PDI scores and MDI scores between the two groups(P<0.05). Conclusion aEEG has diagnostic value for brain injury in premature infants, and early intervention can reduce the brain injury, which is worthy of clinical promotion and application.
Key words:  Premature infants  Amplitude integrated electroencephalogram(aEEG)  Brain injury  Infant Intelligence Development Scale