引用本文:苏恒学,梁 亮,李友琼,田 矛,覃 婷.血红蛋白E病中血红蛋白A2和血红蛋白F水平及其分布研究[J].中国临床新医学,2019,12(12):1300-1302.
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血红蛋白E病中血红蛋白A2和血红蛋白F水平及其分布研究
苏恒学,梁 亮,李友琼,田 矛,覃 婷
537500 广西,容县人民医院检验科(苏恒学);530021 南宁,广西壮族自治区人民医院产前诊断中心(梁 亮,李友琼,田 矛,覃 婷)
摘要:
[摘要] 目的 了解血红蛋白E(Hb E)病中血红蛋白A2(Hb A2)和血红蛋白F(Hb F)水平及其分布规律。方法 选择Hb E病样本170例,以基因分析结果分为Hb E杂合子组、Hb E纯合子组、Hb E合并α地中海贫血(简称地贫)组和Hb E合并β地贫组。采用毛细管电泳法分析Hb A2及Hb F的水平及其在各组的分布情况。结果 Hb E杂合子组125例,Hb E纯合子组5例,Hb E合并α地贫组21例,Hb E合并β地贫组19例,四组的Hb A2平均水平分别为(3.66±0.38)%、(9.64±0.76)%、(3.70±0.37)%和(5.83±1.49)%。Hb E纯合子组和Hb E合并β地贫组的Hb F水平分别为(5.22±3.90)%和(36.81±13.97)%。Hb E合并β地贫组和Hb E纯合子组Hb A2水平主要落在高值区域(Hb A2≥4.0%),其他两组主要是低值(2.5%结论 在Hb E病中,Hb A2和Hb F的水平及其分布频率因基因型不同而不同,一般随着疾病严重程度而升高。
关键词:  血红蛋白E病  毛细管电泳  血红蛋白A2  血红蛋白F
DOI:10.3969/j.issn.1674-3806.2019.12.11
分类号:R 556.7
基金项目:广西卫健委科研课题(编号:Z2011449)
Study on the levels and distributions of hemoglobin A2 and hemoglobin F in hemoglobin E disease
SU Heng-xue, LIANG Liang, LI You-qiong, et al.
Department of Clinical Laboratory, the People′s Hospital of Rongxian, Guangxi 537500, China
Abstract:
[Abstract] Objective To study the levels and distributions of hemoglobin A2(Hb A2) and hemoglobin F(Hb F) in hemoglobin E(Hb E) disease. Methods One hundred and seventy samples from the Hb E disease patients were selected and were divided into Hb E heterozygotes group, Hb E homozygotes group, Hb E with α-thalassemia group and Hb E with β-thalassemia group according to the thalassemia gene analysis results. The levels of Hb A2 and Hb F and their distributions in each group were analyzed by capillary electrophoresis. Results The results showed 125 cases in the Hb E heterozygotes group, 5 cases in the Hb E homozygotes group, 21 cases in the Hb E with α-thalassemia group, and 19 cases in the Hb E with β-thalassemia group. The average levels of Hb A2 in the four groups were (3.66±0.38)%, (9.64±0.76)%, (3.70±0.37)% and (5.83±1.49)%, respectively. The level of Hb F was (5.22±3.90)% in the Hb E homozygotes group, and (36.81±13.97)% in the Hb E with β-thalassemia group. In the Hb E homozygotes group and the Hb E with β-thalassemia group, the Hb A2 levels were mainly in the high value region(Hb A2≥4.0%), and in the other two groups the Hb A2 levels were mostly in the low value(2.5%Conclusion In Hb E disease, the levels and distribution frequencies of Hb A2 and Hb F vary with genotypes, and generally increase with the severity of the disease.
Key words:  Hemoglobin E(Hb E) disease  Capillary electrophoresis  Hemoglobin A2(Hb A2)  Hemoglobin F(Hb F)