引用本文:黄伟媚,陈昌益.盆底治疗仪联合重组人粒细胞集落刺激因子宫腔灌注对改善子宫内膜容受性的影响研究[J].中国临床新医学,2019,12(12):1303-1306.
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盆底治疗仪联合重组人粒细胞集落刺激因子宫腔灌注对改善子宫内膜容受性的影响研究
黄伟媚,陈昌益
537100 广西,贵港市人民医院生殖医学中心(黄伟媚);530021 南宁,广西壮族自治区人民医院妇科(陈昌益)
摘要:
[摘要] 目的 探讨盆底治疗仪联合重组人粒细胞集落刺激因子(G-CSF)宫腔灌注对改善子宫内膜容受性的影响。方法 选取2017-02~2018-07在广西贵港市人民医院生殖中心行体外受精(in-vitro fertilization,IVF)助孕的薄型子宫内膜患者60例,均以人工周期准备内膜后行冻融胚胎移植(frozen embryo transfer,FET)。按就诊顺序分为对照组(采用G-CSF宫腔灌注治疗)和观察组(采用G-CSF宫腔灌注联合盆底治疗仪治疗),每组30例。比较两组治疗前后的的子宫内膜厚度(endometrial thickness,Em)、阻力指数(resistance index,RI)、A型子宫内膜率,治疗后的胚胎种植率、妊娠率。结果 治疗后,观察组Em值和A型子宫内膜率大于对照组,RI值低于对照组,差异有统计学意义(P<0.05)。胚胎种植率和妊娠率在治疗后两组比较差异无统计学意义(P>0.05)。结论 盆底功能障碍治疗仪结合G-CSF宫腔灌注可以改善薄型子宫内膜的容受性,增加Em。
关键词:  盆底治疗仪  薄型子宫内膜  重组人粒细胞集落刺激因子  宫腔灌注
DOI:10.3969/j.issn.1674-3806.2019.12.12
分类号:R 771
基金项目:贵港市科学研究与技术开发计划项目(编号:贵科转1701007)
Effects of pelvic floor therapeutic apparatus combined with recombinant human granulocyte-colony stimulating factor for intrauterine perfusion on improving endometrial receptivity
HUANG Wei-mei, CHEN Chang-yi
Reproductive Medicine Centre, the People′s Hospital of Guigang City, Guangxi 537100, China
Abstract:
[Abstract] Objective To investigate the effects of pelvic floor therapeutic apparatus combined with recombinant human granulocyte-colony stimulating factor(G-CSF) for intrauterine perfusion on improving endometrial receptivity. Methods Sixty patients wtih thin endometria were selected from the Reproductive Medicine Centre of the People′s Hospital of Guigang City for in-vitro fertilization(IVF) assisted pregnancy during February 2017 and July 2018. All the patients were prepared for artificial cycles and then underwent frozen-thawed embryo transfer(FET). According to the visiting order, the patients were divided into the control group(treated with G-CSF for intrauterine perfusion) and the observation group(treated with G-CSF for intrauterine perfusion combined with pelvic floor therapeutic apparatus), with 30 cases in each group. The endometrial thickness(Em), resistance index(RI) and the proportion of type A endometria were compared between the two groups before and after treatment. The embryo implantation rate and the pregnancy rate were compared between the two groups after treatment. Results After treatment, the Em value and the type A endometrium rate of the observation group were significantly greater than those of the control group, and the RI value of the observation group was significantly less than that of the control group(P<0.05). There were no significant differences in the embryo implantation rate and the pregnancy rate between the two groups after treatment(P>0.05). Conclusion The pelvic floor therapeutic apparatus combined with G-CSF for intrauterine perfusion can improve the endometrial receptivity of the thin endometria and increase the Em.
Key words:  Pelvic floor therapeutic apparatus  Thin endometria  Recombinant human granulocyte-colony stimulating factor(G-CSF)  Intrauterine perfusion