引用本文:朱 琳,宋春兰,崔亚杰,李 鹏.手足口病患儿血清脂联素和胰岛素样生长因子-1水平变化及其临床意义[J].中国临床新医学,2020,13(4):381-385.
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手足口病患儿血清脂联素和胰岛素样生长因子-1水平变化及其临床意义
朱 琳,宋春兰,崔亚杰,李 鹏
450000 河南,郑州大学附属儿童医院,河南省儿童医院,郑州儿童医院重症监护室
摘要:
[摘要] 目的 探讨手足口病(hand-foot-mouth disease,HFMD)患儿血清脂联素(adiponectin,APN)、胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)水平变化及其临床意义。方法 选择2016-03~2017-12河南省儿童医院收治的HFMD患儿114例,其中普通型组53例,重型组46例,危重型组15例,测定入院时、入院5 d时血清APN、IGF-1水平;另选择40名健康儿童作为正常对照组。比较各组血清APN、IGF-1水平。结果 重型组及危重型组HFMD患儿入院时血清APN、IGF-1水平较普通型组、对照组明显下降,差异有统计学意义(P<0.05)。入院5 d时,患儿血清APN、IGF-1水平显著升高,但重型组及危重型组仍低于普通型组,差异有统计学意义(P<0.05)。结论 重型及危重型HFMD患儿脑损害明显,血清APN、IGF-1水平降低与病情严重程度相关,对病情及预后的判断具有指导意义。
关键词:  手足口病  脂联素  胰岛素样生长因子-1
DOI:10.3969/j.issn.1674-3806.2020.04.15
分类号:R 725.1
基金项目:
Changes and significances of serum adiponectin and insulin-like growth factor-1 in children with hand-foot-mouth disease
ZHU Lin, SONG Chun-lan, CUI Ya-jie, et al.
Department of Intensive Care Unit, the Children′s Hospital Affiliated to Zhengzhou University, Henan Children′s Hospital, Zhengzhou Children′s Hospital, Henan 450000, China
Abstract:
[Abstract] Objective To investigate the changes of serum adiponectin(APN) and insulin-like growth factor-1(IGF-1) levels in children with hand-foot-mouth disease(HFMD) and their clinical value. Methods During March 2016 and December 2017, 114 children with HFMD were selected from Henan Children′s Hospital, including 53 cases in the general type group, 46 cases in the severe type group and 15 cases in the critical type group. The serum levels of APN and IGF-1 were detected at admission and 5 days after admission. Other 40 healthy children were selected as the control group. The serum levels of APN and IGF-1 were compared among the four groups. Results The serum levels of APN and IGF-1 of HFMD patients in the severe type group and the critical type group were significantly lower than those in the general type group and the control group(P<0.05). On the 5th day after admission, the serum levels of APN and IGF-1 of the patients increased significantly. However, the levels of APN and IGF-1 in the severe type group and the critical type group were still lower than those in the general type group(P<0.05). Conclusion Severe and critical HFMD children have obvious brain damage. The decrease of serum APN and IGF-1 levels is related to the severity of the disease, and is of guiding significance for the disease evaluation and the prediction of prognosis.
Key words:  Hand-foot-mouth disease(HFMD)  Adiponectin(APN)  Insulin-like growth factor-1(IGF-1)