引用本文:李 卫(综述),刘 斐(审校).EB病毒血清学指标筛查鼻咽癌的研究进展[J].中国临床新医学,2020,13(4):409-415.
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EB病毒血清学指标筛查鼻咽癌的研究进展
李 卫(综述),刘 斐(审校)
530021 南宁,广西壮族自治区人民医院健康管理中心(李 卫),科研实验中心(刘 斐)
摘要:
[摘要] 鼻咽癌在我国华南地区高发,早诊早治可提高鼻咽癌患者的生存率,因此提高该地区人群早期鼻咽癌检出率十分关键。EB病毒(Epstein-Barr virus,EBV)感染鼻咽上皮细胞是导致鼻咽癌发生的重要因素,EBV多种基因分别表达R反式激活因子(R transactivator,Rta)、Z反式激活因子(Z transactivator,Zta)、早期抗原(early antigen,EA)和病毒衣壳抗原(viral capsid antigen,VCA)以及EB病毒核抗原1(EBV nuclear antigen 1,EBNA1)等多种蛋白,由此在人体血清中产生以免疫球蛋白G(immunoglobulin G,IgG)和免疫球蛋白A(immunoglobulin A,IgA)为主的抗体,其中Rta-IgG、Zta-IgG/IgA、EA-IgA、VCA-IgA、EBNA1-IgA/IgG为鼻咽癌的特异标志物。该文综述相关基因及其表达蛋白的生物学特性,以及应用这些血清学标志物筛查鼻咽癌高发区人群的诊断价值,为开展早期筛查鼻咽癌研究提供依据。
关键词:  鼻咽癌  EB病毒  血清学指标  生物学特性
DOI:10.3969/j.issn.1674-3806.2020.04.24
分类号:R 739.62
基金项目:国家自然科学基金项目(编号:81960493);广西卫健委科研课题(编号:Z20180759)
Research progress of serological markers of Epstein-Barr virus in screening nasopharyngeal carcinoma
LI Wei, LIU Fei
Health Management Center, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
Abstract:
[Abstract] Nasopharyngeal carcinoma(NPC) has a high incidence rate in South China. Early diagnosis and early therapy can improve the survival rate of NPC patients. Therefore, it is very important to improve the detection rate of early NPC in the population of South China.An important factor causing NPC is that nasopharyngeal epithelial cells are infected by Epstein-Barr virus(EBV). Some genes of EBV express a variety of proteins, such as R transactivator(Rta), Z transactivator(Zta), early antigen(EA), viral capsid antigen(VCA) and EBV nuclear antigen 1(EBNA1). Therefore, the main antibodies including immunoglobulin G(IgG) and immunoglobulin A(IgA) are formed in the serum of human body, among which Rta-IgG, Zta-IgG/IgA, EA-IgA, VCA-IgA and EBNA-IgA/IgG are specific markers of NPC. In this paper, we review the biological characteristics of the related genes and their expressed proteins, as well as the diagnostic value of these serological markers in screening the population in the high incidence area of NPC, so as to provide a basis for early screening of NPC.
Key words:  Nasopharyngeal carcinoma(NPC)  Epstein-Barr virus(EBV)  Serological markers  Biological characteristics