引用本文:隋 鑫,牛玉林(综述),李 昆(审校).自噬与心肌病相关性的研究进展[J].中国临床新医学,2020,13(4):415-419.
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自噬与心肌病相关性的研究进展
隋 鑫,牛玉林(综述),李 昆(审校)
550025 贵阳,贵州医科大学附属医院急诊科(隋 鑫),移植科(牛玉林),普通外科(李 昆)
摘要:
[摘要] 自噬这个词来源于希腊语,原意为“吃自己”和“精确的细胞作用”。自噬从最初发现到如今经历了近50年,研究发现自噬可以被许多刺激所激活,包括饥饿、毒素、氧化应激和感染。在正常情况下,心肌细胞自噬维持在较低的情况,但在应激反应的高度激活下,自噬活动增强并在调节心脏稳态和功能中起重要作用。该文对自噬与心肌病相关性的研究进展进行综述。
关键词:  自噬  心肌病  人自噬基因编码蛋白-1  微管相关蛋白1轻链3
DOI:10.3969/j.issn.1674-3806.2020.04.25
分类号:R 542.2
基金项目:贵州省科技合作计划项目(编号:TN2015-74)
Advances in studies on correlation between autophagy and cardiomyopathy
SUI Xin, NIU Yu-lin, LI Kun
Department of Emergency, the Affiliated Hospital of Guizhou Medical University, Guiyang 550025, China
Abstract:
[Abstract] The word autophagy comes from Greek, meaning “eating oneself” and “precise cellular action”. It has been nearly 50 years since autophagy was first discovered. It has been found that autophagy can be activated by many stimuli, including hunger, toxins, oxidative stress and infection. Under normal conditions, autophagy of cardiomyocytes is maintained at a low level, but under high activation of stress response, autophagy activity is enhanced and plays an important role in regulating cardiac homeostasis and function. This paper reviews the research progress on the correlation between autophagy and cardiomyopathy.
Key words:  Autophagy(Atg)  Cardiomyopathy  Beclin-1  Microtubule-associated protein 1 light chain 3(LC3)