引用本文:彭 芳,孙夫东,叶新民,许宝华,孟 超.金黄色葡萄球菌耐药率与抗菌药物使用量的相关性分析[J].中国临床新医学,2020,13(5):491-495.
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金黄色葡萄球菌耐药率与抗菌药物使用量的相关性分析
彭 芳,孙夫东,叶新民,许宝华,孟 超
273300 山东,平邑县人民医院临床药学科(彭 芳,孙夫东,孟 超);330006 南昌,南昌大学江西医学院(叶新民,许宝华)
摘要:
[摘要] 目的 分析金黄色葡萄球菌耐药率与抗菌药物使用量的相关性,为临床合理使用抗菌药物提供参考依据。方法 回顾性分析该院2014~2018年8类抗菌药物的用药频度和金黄色葡萄球菌的耐药率情况,采用Pearson相关分析法分析各类抗菌药物限定日剂量累积数(DDDs)与金黄色葡萄球菌耐药率的相关性。结果 金黄色葡萄球菌的青霉素耐药率与第3代头孢菌素(r=0.912)和喹诺酮类(r=0.940)抗菌药物的DDDs呈正相关(P<0.05)。苯唑西林耐药率与含酶抑制剂复方制剂的DDDs呈正相关(r=0.902,P<0.05)。金黄色葡萄球菌对左氧氟沙星的耐药率与第1代头孢菌素(r=0.949)以及大环内酯类(r=0.861)抗菌药物的DDDs呈高度正相关(P<0.05),与含酶抑制剂复方制剂DDDs呈高度负相关(r=-0.852,P<0.05)。克林霉素耐药率与第1代头孢菌素抗菌药物DDDs呈高度正相关(r=0.921,P<0.05)。结论 抗菌药物的DDDs与金黄色葡萄球菌的耐药率之间存在一定的相关性且关系复杂。
关键词:  金黄色葡萄球菌  耐药率  抗菌药物  相关性
DOI:10.3969/j.issn.1674-3806.2020.05.15
分类号:R 978.1;R 969
基金项目:江西省重点实验室计划项目(编号:20192BCD40003)
Study on the correlation between drug-resistant rate of Staphylococcus aureus and consumption of antibacterial agents
PENG Fang, SUN Fu-dong, YE Xin-min, et al.
Department of Clinical Pharmacy, the People′s Hospital of Pingyi County, Shandong 273300, China
Abstract:
[Abstract] Objective To investigate the correlation between the drug-resistant rate of Staphylococcus aureus and the consumption of antibacterial agents, and to provide a reference for the rational use of antibacterial agents in clinical practice. Methods A retrospective analysis of the frequency of use of eight types of antibacterial agents and the drug-resistant rate of Staphylococcus aureus was performed in our hospital from 2014 to 2018, and the correlation between the antibacterial drug cumulative defined daily doses(DDDs) and the drug-resistant rate of Staphylococcus aureus was analyzed using Pearson correlation analysis. Results The penicillin resistance rate of Staphylococcus aureus was positively correlated with DDDs of the third-generation cephalosporins(r=0.912) and quinolones(r=0.940) antibacterials(P<0.05). The rate of oxacillin resistance was positively correlated with DDDs of the compound preparations containing enzyme inhibitors(r=0.902, P<0.05). The resistance rate of Staphylococcus aureus to levofloxacin was highly positively correlated with DDDs of the first-generation cephalosporins(r=0.949) and macrolides(r=0.861) antibacterials(P<0.05), and was highly negatively correlated with DDDs of the compound preparations containing enzyme inhibitors(r=-0.852, P<0.05). The clindamycin resistance rate were highly positively correlated with DDDs of the first-generation cephalosporins(r=0.921, P<0.05). Conclusion There is a certain correlation and complex relationship between DDDs of antibacterial agents and drug-resistance rates of Staphylococcus aureus.
Key words:  Staphylococcus aureus  Drug-resistant rate  Antibacterial agents  Correlation