| 摘要: |
| ［摘要］ 目的 分析金黄色葡萄球菌耐药率与抗菌药物使用量的相关性，为临床合理使用抗菌药物提供参考依据。方法 回顾性分析该院2014～2018年8类抗菌药物的用药频度和金黄色葡萄球菌的耐药率情况，采用Pearson相关分析法分析各类抗菌药物限定日剂量累积数（DDDs）与金黄色葡萄球菌耐药率的相关性。结果 金黄色葡萄球菌的青霉素耐药率与第3代头孢菌素（r=0.912）和喹诺酮类（r=0.940）抗菌药物的DDDs呈正相关（P<0.05）。苯唑西林耐药率与含酶抑制剂复方制剂的DDDs呈正相关（r=0.902，P<0.05）。金黄色葡萄球菌对左氧氟沙星的耐药率与第1代头孢菌素（r=0.949）以及大环内酯类（r=0.861）抗菌药物的DDDs呈高度正相关（P<0.05），与含酶抑制剂复方制剂DDDs呈高度负相关（r=-0.852，P<0.05）。克林霉素耐药率与第1代头孢菌素抗菌药物DDDs呈高度正相关（r=0.921，P<0.05）。结论 抗菌药物的DDDs与金黄色葡萄球菌的耐药率之间存在一定的相关性且关系复杂。 |
| 关键词: 金黄色葡萄球菌 耐药率 抗菌药物 相关性 |
| DOI：10.3969/j.issn.1674-3806.2020.05.15 |
| 分类号:R 978.1；R 969 |
| 基金项目:江西省重点实验室计划项目（编号：20192BCD40003） |
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| Study on the correlation between drug-resistant rate of Staphylococcus aureus and consumption of antibacterial agents |
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PENG Fang, SUN Fu-dong, YE Xin-min, et al.
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Department of Clinical Pharmacy, the People′s Hospital of Pingyi County, Shandong 273300, China
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| Abstract: |
| ［Abstract］ Objective To investigate the correlation between the drug-resistant rate of Staphylococcus aureus and the consumption of antibacterial agents, and to provide a reference for the rational use of antibacterial agents in clinical practice. Methods A retrospective analysis of the frequency of use of eight types of antibacterial agents and the drug-resistant rate of Staphylococcus aureus was performed in our hospital from 2014 to 2018, and the correlation between the antibacterial drug cumulative defined daily doses(DDDs) and the drug-resistant rate of Staphylococcus aureus was analyzed using Pearson correlation analysis. Results The penicillin resistance rate of Staphylococcus aureus was positively correlated with DDDs of the third-generation cephalosporins(r=0.912) and quinolones(r=0.940) antibacterials(P<0.05). The rate of oxacillin resistance was positively correlated with DDDs of the compound preparations containing enzyme inhibitors(r=0.902, P<0.05). The resistance rate of Staphylococcus aureus to levofloxacin was highly positively correlated with DDDs of the first-generation cephalosporins(r=0.949) and macrolides(r=0.861) antibacterials(P<0.05), and was highly negatively correlated with DDDs of the compound preparations containing enzyme inhibitors(r=-0.852, P<0.05). The clindamycin resistance rate were highly positively correlated with DDDs of the first-generation cephalosporins(r=0.921, P<0.05). Conclusion There is a certain correlation and complex relationship between DDDs of antibacterial agents and drug-resistance rates of Staphylococcus aureus. |
| Key words: Staphylococcus aureus Drug-resistant rate Antibacterial agents Correlation |
