引用本文:林上闹(综述),余 建(审校).异基因造血干细胞移植后中枢神经系统移植物抗宿主病的研究进展[J].中国临床新医学,2020,13(5):522-526.
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异基因造血干细胞移植后中枢神经系统移植物抗宿主病的研究进展
林上闹(综述),余 建(审校)
310003 杭州,浙江大学医学院附属第一医院骨髓移植中心
摘要:
[摘要] 异基因造血干细胞移植(allogeneic hematopoietic stem cell transplantation,allo-HSCT)是目前治疗血液系统恶性肿瘤最有效的手段之一,中枢神经系统移植物抗宿主病(central nervous system graft-versus-host disease,CNS-GVHD)是allo-HSCT术后少见且严重的并发症。该文基于国内外CNS-GVHD的病例报道和研究,对其发病机制、分型、临床表现、诊断及治疗进行综述。
关键词:  异基因造血干细胞移植  中枢神经系统并发症  移植物抗宿主病
DOI:10.3969/j.issn.1674-3806.2020.05.24
分类号:R 55
基金项目:国家自然科学基金面上项目(编号:81970137)
Research progress of central nervous system graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
LIN Shang-nao, YU Jian
Center of Bone Marrow Transplantation, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003,China
Abstract:
[Abstract] Allogeneic hematopoietic stem cell transplantation(allo-HSCT) is an aggressive and effective treatment for hematological malignancies. Central nervous system graft-versus-host disease(CNS-GVHD) is one of the rare and fierce complications after allo-HSCT. Based on the case reports and studies of CNS-GVHD at home and abroad, we review its pathogenesis, classification, clinical manifestations, diagnosis and treatment in this paper.
Key words:  Allogeneic hematopoietic stem cell transplantation(allo-HSCT)  Central nervous system complication(CNSC)  Graft-versus-host disease(GVHD)