| 摘要: |
| ［摘要］ 异基因造血干细胞移植（allogeneic hematopoietic stem cell transplantation，allo-HSCT）是目前治疗血液系统恶性肿瘤最有效的手段之一，中枢神经系统移植物抗宿主病（central nervous system graft-versus-host disease,CNS-GVHD）是allo-HSCT术后少见且严重的并发症。该文基于国内外CNS-GVHD的病例报道和研究，对其发病机制、分型、临床表现、诊断及治疗进行综述。 |
| 关键词: 异基因造血干细胞移植 中枢神经系统并发症 移植物抗宿主病 |
| DOI：10.3969/j.issn.1674-3806.2020.05.24 |
| 分类号:R 55 |
| 基金项目:国家自然科学基金面上项目（编号：81970137） |
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| Research progress of central nervous system graft-versus-host disease after allogeneic hematopoietic stem cell transplantation |
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LIN Shang-nao, YU Jian
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Center of Bone Marrow Transplantation, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003,China
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| Abstract: |
| ［Abstract］ Allogeneic hematopoietic stem cell transplantation(allo-HSCT) is an aggressive and effective treatment for hematological malignancies. Central nervous system graft-versus-host disease(CNS-GVHD) is one of the rare and fierce complications after allo-HSCT. Based on the case reports and studies of CNS-GVHD at home and abroad, we review its pathogenesis, classification, clinical manifestations, diagnosis and treatment in this paper. |
| Key words: Allogeneic hematopoietic stem cell transplantation(allo-HSCT) Central nervous system complication(CNSC) Graft-versus-host disease(GVHD) |
