引用本文:李辛岚,王耶盈(综述),李永霞(审校).TLR4与慢性间歇性低氧诱导炎症反应机制的研究进展[J].中国临床新医学,2020,13(9):936-940.
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TLR4与慢性间歇性低氧诱导炎症反应机制的研究进展
李辛岚,王耶盈(综述),李永霞(审校)
650101 云南,昆明医科大学第二附属医院呼吸与危重症二病区(李辛岚,李永霞);650500 云南,昆明医科大学公共卫生学院(王耶盈)
摘要:
[摘要] 慢性间歇性低氧(chronic intermittent hypoxia,CIH)是阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea syndrome,OSAS)的典型生理病理特征之一,是导致OSAS多器官系统损伤的关键起始因素。而Toll样受体4(Toll-like receptor 4,TLR4)作为一种高度保守的免疫受体,参与多种炎症反应及炎症级联反应。近年来,TLR4信号通路在CIH诱导炎症反应中的作用已经引起了越来越多的关注和研究,为OSAS的诊断及治疗提供了新靶点。该文从CIH、TLR4、TLR4基因沉默实验及拮抗剂等方面的最新研究进展进行综述。
关键词:  慢性间歇性低氧  TOLL样受体4  炎症反应  基因沉默实验
DOI:10.3969/j.issn.1674-3806.2020.09.23
分类号:R 563.9
基金项目:云南省教育厅科学研究基金项目(编号:2017zzx198)
Research progress of TLR4 and the reaction mechanism of chronic intermittent hypoxia inducing inflammation
LI Xin-lan, WANG Ye-ying, LI Yong-xia
The Second Ward of the Department of Respiratory and Critical Medicine, the Second Affiliated Hospital of Kunming Medical University, Yunnan 650101, China
Abstract:
[Abstract] Chronic intermittent hypoxia(CIH) is one of the typical physiological and pathological characteristics of obstructive sleep apnea syndrome(OSAS), and is a key initial factor leading to multi-organ system injury of OSAS. Toll-like receptor 4(TLR4), as a highly conserved immune receptor, participates in a variety of inflammatory responses and inflammatory cascades. In recent years, the role of TLR4 signaling pathway in CIH inducing inflammatory response has attracted more and more attention and research, providing new targets for the diagnosis and treatment of OSAS. In this paper, we review the recent advances in CIH, TLR4, TLR4 gene silencing technology and antagonists.
Key words:  Chronic intermittent hypoxia(CIH)  Toll-like receptor 4(TLR4)  Inflammatory response  Gene silencing experiment