引用本文:吴迎迎,丁 丽,杨瑞雪,巩幼洁,郭冰沁.腹膜播散性平滑肌瘤病4例临床病理学特征分析及文献复习[J].中国临床新医学,2020,13(12):1254-1257.
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腹膜播散性平滑肌瘤病4例临床病理学特征分析及文献复习
吴迎迎,丁 丽,杨瑞雪,巩幼洁,郭冰沁
233000 安徽,蚌埠医学院第一附属医院病理科
摘要:
[摘要] 目的 探讨腹膜播散性平滑肌瘤病(LPD)的临床病理学特征、诊断及鉴别诊断。方法 回顾性分析4例LPD患者的临床病理学特征、组织学形态及免疫表型并复习相关文献。结果 4例均为女性,年龄32~51岁。镜检:肿瘤由梭形细胞组成,呈编织状排列,胞浆红染,核呈杆状,细胞大小较一致,无核分裂象。免疫表型:瘤细胞表达平滑肌肌动蛋白(SMA)、结蛋白(desmin)、Ki-67,而CD117、CD34、S-100、DOG-1均为阴性。结论 LPD是一种罕见的良性肿瘤,预后良好,诊断主要依赖其组织病理学特征及免疫表型。
关键词:  腹膜播散性平滑肌瘤病  免疫组织化学  鉴别诊断
DOI:10.3969/j.issn.1674-3806.2020.12.17
分类号:R 735.4
基金项目:
Leiomyomatosis peritonealis disseminata: a clinicopathological feature analysis of 4 cases and review of literatures
WU Ying-ying, DING Li, YANG Rui-xue, et al.
Department of Pathology, the First Affiliated Hospital of Bengbu Medical College, Anhui 233000, China
Abstract:
[Abstract] Objective To investigate the clinicopathological features, diagnosis and differential diagnosis of leiomyomatosis peritonealis disseminata(LPD). Methods The clinicopathological features, histological morphology and immunophenotype of 4 patients with LPD were retrospectively analyzed and the relevant literatures were reviewed. Results All of the 4 cases were female, aged 32~51 years. Microscopy: The tumors were consisted of relatively uniform spindle cells in an interlacing arrangement, cytoplasmic red staining, rod-shaped nuclei and rare mitosis. Immunophenotype: The tumor cells expressed smooth muscle actin(SMA), desmin and Ki-67, while CD117, CD34, S-100 and DOG-1 were all negative. Conclusion LPD is a rare benign tumor with a good prognosis. Its diagnosis mainly depends on its histopathological characteristics and immunophenotype.
Key words:  Leiomyomatosis peritonealis disseminata(LPD)  Immunohistochemistry  Differential diagnosis