引用本文:杨建荣,刘天奇,郑树森,董小锋.VETC癌巢型肝细胞癌的研究进展[J].中国临床新医学,2021,14(6):529-533.
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VETC癌巢型肝细胞癌的研究进展
杨建荣,刘天奇,郑树森,董小锋
530021 南宁,广西医学科学院,广西壮族自治区人民医院肝胆胰脾外科(杨建荣,刘天奇,董小锋);310000 杭州,浙江大学附属第一医院肝胆胰外科(郑树森)
摘要:
[摘要] 肝癌的复发转移是影响肝癌患者预后的关键。血管包绕肿瘤细胞巢(VETC)癌巢型肝细胞癌的转移方式无法用上皮-间质转化(EMT)理论来解释,其可以内皮细胞包绕肿瘤细胞团的形式发生整体转移,转移过程中肿瘤细胞不会发生EMT,VETC癌巢型肝细胞癌更易发生转移,转移效率更高,术后更易复发,预后更差。该文对VETC癌巢型肝细胞癌的分型、分子学特征、诊断、治疗及预后等进行评价和介绍,从而提高临床医师及研究人员对该类肝癌诊治的认识。
关键词:  肝细胞癌  血管包绕肿瘤细胞巢  诊断  治疗  预后
DOI:10.3969/j.issn.1674-3806.2021.06.01
分类号:R 735.7
基金项目:国家自然科学基金项目(编号:81560406)
Research progress of VETC carcinoma nest-type hepatocellular carcinoma
YANG Jian-rong, LIU Tian-qi, ZHENG Shu-sen, et al.
Department of Hepatobiliary, Pancreas and Spleen Surgery, Guangxi Academy of Medical Sciences, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
Abstract:
[Abstract] Relapse and metastasis are the key factors affecting the prognosis of patients with hepatocellular carcinoma(HCC). The metastasis mechanisms of vessels encapsulated tumor clusters(VETC) carcinoma nest-type HCC can not be explained by the theory of epithelial-to-mesenchymal transition(EMT). In VETC carcinoma nest-type HCC, tumor cells do not metastasize through EMT, but metastasize to other organs in carcinoma nest form in which VETC carcinoma nest-type HCC is encapsulated by endothelial cells. VETC carcinoma nest-type HCC is more likely to have metastasis and higher metastatic efficiency, and is more likely to relapse after operation, resulting in a worse prognosis. This paper evaluates and introduces the classification, molecular characteristics, diagnosis, treatment and prognosis of VETC carcinoma nest-type HCC, so as to improve the understanding of clinicians and researchers on the diagnosis and treatment of VETC carcinoma nest-type HCC.
Key words:  Hepatocellular carcinoma(HCC)  Vessels encapsulated tumor clusters(VETC)  Diagnosis  Therapy  Prognosis