| 摘要: |
| ［摘要］ 目的 探讨生芪降糖方联合二甲双胍缓释片治疗气阴两虚型2型糖尿病的临床疗效。方法 选择2019年12月至2020年11月白银市中西医结合医院内分泌科收治的气阴两虚型2型糖尿病患者80例，以就诊顺序分为研究组和对照组，每组40例。对照组予二甲双胍缓释片治疗，研究组在对照组的治疗方案基础上加用生芪降糖方，疗程均为4周。比较两组治疗前后空腹血糖（FPG）、糖负荷后2小时血糖(2hPG)、糖化血红蛋白（HbA1c）、低密度脂蛋白胆固醇（LDL-C）、同型半胱氨酸（Hcy）水平，以及体质量指数（BMI）和中医证候积分。观察两组的临床疗效以及不良反应发生情况。结果 两组治疗后FPG、2hPG、HbA1c、LDL-C、Hcy、BMI水平以及中医证候积分均较治疗前显著降低（P<0.05），且研究组较对照组更低，差异有统计学意义（P<0.05）。研究组总有效率显著高于对照组（87.50% vs 50.00%； χ2=10.751，P=0.001）。两组不良反应发生率比较差异无统计学意义（P>0.05）。结论 与单纯使用二甲双胍缓释片比较，生芪降糖方联合二甲双胍缓释片治疗气阴两虚型2型糖尿病的疗效更优，且安全性好，值得临床推广。 |
| 关键词: 气阴两虚 2型糖尿病 二甲双胍缓释片 生芪降糖方 疗效 |
| DOI：10.3969/j.issn.1674-3806.2021.10.11 |
| 分类号:R 587.1 |
| 基金项目:陇原青年创新创业人才项目（编号：2020RCXM165）；甘肃省中医药管理局科研课题（编号：GZK-2019-7） |
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| A study on therapeutic effect of Shengqi Jiangtang Prescription combined with metformin sustained-release tablets on type 2 diabetes mellitus with qi-yin deficiency |
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BAI Hong-xia, GAO Yun-feng, YANG Rui-juan, et al.
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Department of Endocrinology, Baiyin Hospital of Integrated Traditional Chinese and Western Medicine, Gansu 730900, China
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| Abstract: |
| ［Abstract］ Objective To explore the clinical efficacy of Shengqi Jiangtang Prescription combined with metformin sustained-release tablets in treatment of type 2 diabetes mellitus with qi-yin deficiency. Methods Eighty patients suffering from type 2 diabetes mellitus with qi-yin deficiency who were admitted to the Department of Endocrinology, Baiyin Hospital of Integrated Traditional Chinese and Western Medicine from December 2019 to November 2020 were selected, and the patients were divided into study group and control group in the order of their treatments, with 40 cases in each group. The control group was treated with metformin sustained-release tablets, and the study group was treated with Shengqi Jiangtang Prescription plus the same treatment as the control group. The course of treatment was 4 weeks in both groups. The levels of fasting plasma glucose(FPG), plasma glucose of 2 hours post glucose-load(2hPG), glycated hemoglobin(HbA1c), low-density lipoprotein cholesterol(LDL-C), homocysteine(Hcy) as well as Body Mass Index(BMI) and Traditional Chinese Medicine(TCM) syndrome scores were compared between the two groups before and after treatment. The clinical efficacy and the incidence of adverse reactions were observed in the two groups. Results After treatment, the levels of FPG, 2hPG, HbA1c, LDL-C, Hcy, BMI and TCM syndrome scores were significantly lower than those before treatment in the two groups(P<0.05), and the post-treatment levels of the study group were significantly lower than those of the control group(P<0.05). The total effective rate of the study group was significantly higher than that of the control group(87.50% vs 50.00%; χ2=10.751, P=0.001), and there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion Compared with metformin sustained-release tablets alone, Shengqi Jiangtang Prescription combined with metformin sustained-release tablets has better efficacy and safety in the treatment of type 2 diabetes mellitus with qi-yin deficiency. The combination therapy is worthy of clinical promotion. |
| Key words: Qi-yin deficiency Type 2 diabetes mellitus Metformin sustained-release tablets Shengqi Jiangtang Prescription Efficacy |
