| 摘要: |
| ［摘要］ 目的 探讨下肢创伤性闭合骨折患者围术期血栓弹力图(TEG)参数与凝血功能、炎症及血液流变学指标的相关性。方法 选取2018年11月至2020年7月广西壮族自治区人民医院收治的81例下肢创伤性闭合骨折患者的临床资料。采用Pearson相关分析探讨TEG参数（R值、K值、α角、MA值）与凝血功能［凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、血小板（PLT）］、炎症［C反应蛋白(CRP)、白细胞(WBC)］和血液流变学指标［血沉(ESR)、红细胞压积(HCT)］的相关性。结果 81例患者中MA值≥68 mm者68例，高凝状态发生率为83.95%。R值与APTT（r=0.287）、FIB(r=0.310)和ESR(r=0.300)呈显著正相关。K值与PLT(r=-0.318)呈显著负相关，与HCT(r=0.471)呈显著正相关。α角与PLT(r=0.347)、ESR(r=0.258)呈显著正相关，与HCT(r=-0.431)呈显著负相关。MA值与APTT(r=0.319)、FIB(r=0.550)、PLT(r=0.626)、CRP(r=0.351)、ESR(r=0.691)呈显著正相关，与HCT(r=-0.420)呈显著负相关。结论 下肢骨折患者围术期TEG参数与凝血功能、炎症及血液流变学指标具有一定的相关性，可为临床评估患者病情提供参考。 |
| 关键词: 下肢创伤性闭合骨折 血栓弹力图 凝血功能 炎症 血液流变学 |
| DOI：10.3969/j.issn.1674-3806.2021.12.14 |
| 分类号:R 683.42 |
| 基金项目:广西卫生健康委科研课题（编号：Z2015343，Z20180732） |
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| A study on the correlation between perioperative thromboelastography parameters and the indexes of coagulation function, inflammation and hemorheology in patients with traumatic closed fracture of lower extremity |
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LIAO Xiang-cheng, SUN Ke, MO Zhu-ning, et al.
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Department of Blood Transfusion, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To explore the correlation between perioperative thromboelastography(TEG) parameters and the indexes of coagulation function, inflammation and hemorheology in patients with traumatic closed fracture of lower extremity. Methods The clinical data of 81 patients with traumatic closed fracture of lower extremity admitted to the People′s Hospital of Guangxi Zhuang Autonomous Region from November 2018 to July 2020 were selected. Pearson correlation analysis was used to explore the correlation between TEG parameters(R value, K value, α angle, MA value) and the indexes of coagulation function［prothrombin time(PT), activated partial thromboplastin time(APTT), fibrinogen(FIB), platelet(PLT)］, inflammation［C-reactive protein(CRP), white blood cell(WBC)］ and hemorheology［erythrocyte sedimentation rate(ESR), hematocrit(HCT)］. Results Among the 81 patients, there were 68 cases with MA value ≥68 mm, and the incidence of hypercoagulability was 83.95%. R value was significantly positively correlated with APTT(r=0.287), FIB(r=0.310) and ESR(r=0.300). K value was significantly negatively correlated with PLT(r=-0.318), and significantly positively correlated with HCT(r=0.471). α angle was significantly positively correlated with PLT(r=0.347) and ESR(r=0.258), and significantly negatively correlated with HCT(r=-0.431). MA value was significantly positively correlated with APTT(r=0.319), FIB(r=0.550), PLT(r=0.626), CRP(r=0.351) and ESR(r=0.691), and significantly negatively correlated with HCT(r=-0.420). Conclusion The perioperative TEG parameters of patients with lower limb fracture have a certain correlation with the indexes of blood coagulation function, inflammation and hemorheology, which can provide reference for clinical evaluation of the patients′ conditions. |
| Key words: Traumatic closed fracture of lower extremity Thromboelastography(TEG) Coagulation function Inflammation Hemorheology |
