| 摘要: |
| ［摘要］ 目的 分析股腘型下肢动脉硬化闭塞症（ASO）介入治疗术后复发的影响因素。方法 收集2018年5月至2020年2月合肥市第二人民医院接受介入治疗的96例股腘型ASO患者临床资料，经门诊及电话随访2年，评价患肢血管通畅情况。通过二元logistic回归分析ASO介入术后复发的危险因素，采用受试者工作特征（ROC）曲线分析目标变量预测介入术后复发的效能。结果 介入治疗术后2年的复发率为44.8%（43/96）。单因素分析结果显示，泛大西洋学会联盟（TASC Ⅱ）分型、单核细胞、红细胞分布宽度、葡萄糖、胱抑素C、同型半胱氨酸与术后复发具有关联性（P<0.05）。多因素二元logistic回归分析结果表明，TASC Ⅱ分型（OR=3.334，95%CI=1.579～7.039，P=0.002）、胱抑素C（OR=3.108，95%CI=1.149～8.406，P=0.025）是术后复发的独立危险因素，平均红细胞体积（OR=0.895，95%CI=0.806～0.995，P=0.040）是术后复发的独立保护因素。ROC曲线分析结果显示，联合TASCⅡ分型、胱抑素C、平均红细胞体积可有效预测术后复发（AUC=0.776，P=0.000）。结论 TASCⅡ分型、胱抑素C联合平均红细胞体积对患者预后具有一定的预测价值。可通过保护肾功能，降低胱抑素C或提高平均红细胞体积来降低患者介入术后复发的风险。 |
| 关键词: 下肢动脉硬化闭塞症 介入治疗 复发 危险因素 |
| DOI：10.3969/j.issn.1674-3806.2022.09.07 |
| 分类号:R 543.5 |
| 基金项目:安徽省中央引导地方科技惠民示范项目（编号：202007d07050004） |
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| Analysis on the factors affecting the recurrence of femoropopliteal arteriosclerosis obliterans of lower extremity after interventional therapy |
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JIA Xu, PAN Sheng-quan, XIANG Ting-miao, et al.
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Department of Interventional Vascular Pain, Hefei Hospital Affiliated to Anhui Medical University, the Second People′s Hospital of Hefei, Hefei 230011, China
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| Abstract: |
| ［Abstract］ Objective To analyse the factors affecting the recurrence of femoropopliteal arteriosclerosis obliterans(ASO) of lower extremity after interventional therapy. Methods The clinical data of 96 patients with femoropopliteal ASO who received interventional therapy in the Second People′s Hospital of Hefei from May 2018 to February 2020 were collected. The patients were followed up for 2 years by outpatient visit and telephone to evaluate the vascular patency of the affected limbs. Binary logistic regression analysis method was used to analyse the risk factors for recurrence after interventional therapy, and receiver operating characteristic(ROC) curve was used to analyse the efficacy of target variables to predict the recurrence of ASO after interventional therapy. Results The recurrence rate was 44.8%(43/96) 2 years after interventional therapy. The results of univariate analysis showed that Trans-Atlantic Inter-Society Consensus Ⅱ(TASC Ⅱ) type, monocyte, red blood cell distribution width, glucose, cystatin C and homocysteine were the risk factors for postoperative recurrence(P<0.05). The results of multivariate binary logistic regression showed that TASC Ⅱ type(OR=3.334, 95%CI=1.579-7.039, P=0.002) and cystatin C(OR=3.108, 95%CI=1.149-8.406, P=0.025) were the independent risk factors for postoperative recurrence, and mean corpuscular volume(OR=0.895, 95%CI=0.806-0.995, P=0.040) was the independent protective factor for postoperative recurrence(P<0.05). The results of ROC curve analysis showed that the three combined indicators of TASC Ⅱ type, cystatin C and mean corpuscular volume could predict the recurrence after interventional therapy. Conclusion TASC Ⅱ type and cystatin C combined with mean corpuscular volume can have certain predictive value for the prognosis of the patients. The risk of recurrence after interventional therapy can be reduced by protecting renal function and by reducing cystatin C or by increasing mean corpuscular volume. |
| Key words: Arteriosclerosis obliterans(ASO) of lower extremity Interventional therapy Recurrence Risk factors |
