引用本文:王文光,王晨宇,毕 兴,李前跃,宋鸿文,阿斯木江·阿不拉,侯亚坤,王玉杰.2010—2021年新疆地区前列腺癌患者临床特征分析[J].中国临床新医学,2022,15(9):827-831.
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2010—2021年新疆地区前列腺癌患者临床特征分析
王文光,王晨宇,毕 兴,李前跃,宋鸿文,阿斯木江·阿不拉,侯亚坤,王玉杰
830054 乌鲁木齐,新疆医科大学第一附属医院泌尿外科,新疆泌尿男生殖系疾病临床医学研究中心(王文光,宋鸿文,阿斯木江·阿不拉,侯亚坤,王玉杰);830001 乌鲁木齐,新疆维吾尔自治区人民医院泌尿外科(王晨宇);830001 乌鲁木齐,新疆医科大学附属肿瘤医院泌尿外科(毕 兴);830002 乌鲁木齐,新疆生产建设兵团医院泌尿外科(李前跃)
摘要:
[摘要] 目的 分析2010—2021年新疆地区前列腺癌患者的临床特征,为新疆地区的前列腺癌防控策略制定提供参考。方法 收集2010年1月至2021年6月新疆医科大学第一附属医院、新疆维吾尔自治区人民医院、新疆医科大学附属肿瘤医院、新疆生产建设兵团医院收治的2 151例前列腺癌患者的临床资料,对患者的临床特征进行分析。结果 本组患者年龄41~96(71.81±8.20)岁,以70~79岁年龄段居多(1 030例,47.89%);民族以汉族居多(1 477例,68.67%),其次为维吾尔族(500例,23.25%)。从2010年至2021年,发病例数呈增长趋势。初诊时有排尿困难症状者941例(43.75%),占比最高。初诊时患者前列腺特异性抗原(PSA)检测值中位数为54.68 ng/ml,其中≤10.0 ng/ml者299例(13.90%),10.1~20.0 ng/ml者337例(15.67%);>20.0 ng/ml者1 515例(70.43%)。Gleason评分以8分居多,有593例(27.57%)。2 151例患者中1 274例(59.23%)为早期前列腺癌,877例(40.77%)发生远处转移,其中以骨转移为主;438例(20.36%)接受前列腺癌根治术。与汉族患者相比,维吾尔族患者确诊时年龄较小,前列腺体积较大,PSA水平更高,接受前列腺癌根治术的人数比例较低,差异有统计学意义(P<0.05)。汉族患者首发临床表现为体检时发现PSA升高的人数比例大于维吾尔族患者,而维吾尔族患者首发临床表现为尿潴留、排尿困难的人数比例大于汉族患者,差异有统计学意义(P<0.05)。汉族患者肿瘤分型以局限型占比更高,而维吾尔族患者则以远处转移型占比更高,差异有统计学意义(P<0.05)。对于有远处转移者,汉族患者内脏转移发生率及接受系统治疗的人数比例高于维吾尔族患者,维吾尔族患者则以骨转移发生率更高,大多接受单纯内分泌治疗,差异有统计学意义(P<0.05)。结论 新疆地区前列腺癌患者的疾病谱有其独特性,分析其差异特征可为当地制定疾病防控策略提供证据支持。
关键词:  前列腺癌  新疆  临床特征
DOI:10.3969/j.issn.1674-3806.2022.09.10
分类号:R 737.25
基金项目:新疆维吾尔自治区自然科学基金项目(编号:2019D01C314)
An analysis on the clinical characteristics of prostate cancer patients in Xinjiang Uyghur Autonomous Region from 2010 to 2021
WANG Wen-guang, WANG Chen-yu, BI Xing, et al.
Department of Urinary Surgery, the First Affiliated Hospital of Xinjiang Medical University, Xinjiang Clinical Research Center for Urogenital Diseases, Urumqi 830054, China
Abstract:
[Abstract] Objective To analyze the clinical characteristics of prostate cancer patients in Xinjiang Uyghur Autonomous Region from 2010 to 2021, and to provide reference for the formulation of prevention and control strategies for prostate cancer in Xinjiang Uyghur Autonomous Region. Methods The clinical data of 2 151 patients with prostate cancer who were admitted to the First Affiliated Hospital of Xinjiang Medical University, the People′s Hospital of Xinjiang Uyghur Autonomous Region, the Cancer Hospital Affiliated to Xinjiang Medical University, and Xinjiang Production and Construction Corps Hospital from January 2010 to June 2021 were collected. The clinical characteristics of the prostate cancer patients were analyzed. Results The patients in this group were 41-96(71.81±8.20)years old, and most of them were 70-79 years old(1 030 cases, 47.89%). The majority of nationalities were Han nationality(1 477 cases, 68.67%), followed by Uyghur nationality(500 cases, 23.25%). From 2010 to 2021, the number of cases showed an increasing trend. Nine hundred and forty-one cases(43.75%) had dysuria at the time of initial diagnosis. The median prostate-specific antigen(PSA) detection value of the patients at the time of initial diagnosis was 54.68 ng/ml. Two hundred and ninety-nine cases(13.90%) had the PSA detection value ≤10.0 ng/ml, and 337 cases(15.67%) had the PSA detection value in between 10.1 ng/ml and 20.0 ng/ml, and 1 515 cases(70.43%) had the PSA detection value >20.0 ng/ml. Most patients had a Gleason score of 8 points(593 cases, 27.57%). Among the 2 151 patients, 1 274 patients(59.23%) had early-stage prostate cancer, and 877 patients(40.77%) had distant metastasis, mainly bone metastasis, and 438 patients(20.36%) received radical prostatectomy for prostate cancer. Compared with Han patients, Uyghur patients were diagnosed with prostate cancer at a younger age, and had larger prostate volume, higher PSA level, and a lower proportion of patients receiving radical prostatectomy for prostate cancer, and the differences were statistically significant(P<0.05). The proportion of Han patients with increased PSA as the first clinical manifestation during physical examination was greater than that of Uyghur patients, and the proportion of Uyghur patients whose first clinical manifestations were urinary retention and dysuria was greater than that of Han patients, and the differences were statistically significant(P<0.05). The proportion of localized tumor type in Han patients was higher than that in Uyghur patients, while the proportion of distant metastatic tumor type was higher in Uyghur patients, and the differences were statistically significant(P<0.05). For those patients with distant metastases, the incidence of visceral metastases and the proportion of patients receiving systemic therapy in Han patients were higher than those in Uyghur patients, while the incidence of bone metastases was higher in Uyghur patients, most of whom received endocrine therapy alone, and the differences were statistically significant(P<0.05). Conclusion The disease spectrum of prostate cancer patients in Xinjiang Uyghur Autonomous Region is unique, and analyzing its differential characteristics can provide supporting evidence for the local formulation of disease prevention and control strategies.
Key words:  Prostate cancer  Xinjiang  Clinical characteristics