引用本文:孙丽琴,刘甲野,王 辉,何 云,鞠 斌,卢洪洲.多重耐药菌耐药机制及治疗概述[J].中国临床新医学,2022,15(10):921-927.
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多重耐药菌耐药机制及治疗概述
孙丽琴,刘甲野,王 辉,何 云,鞠 斌,卢洪洲
518100 广东,国家感染性疾病临床医学研究中心(深圳市第三人民医院/南方科技大学附属第二医院)感染一科(孙丽琴,王 辉,何 云,鞠 斌,卢洪洲);518060 深圳,深圳大学公共卫生学院(刘甲野)
摘要:
[摘要] 多重耐药菌已成为威胁全球人类健康的一项重大公共卫生问题。提高对多重耐药菌感染的识别能力与治疗效果仍是当前临床上应对多重耐药菌的关键措施。根据不同的耐药机制探索新的替代疗法(如噬菌体)有望在未来成为应对多重耐药菌的突破性技术。该文对多重耐药菌的流行病学、耐药机制和治疗以及新的替代治疗方法进行综述,为临床识别和治疗多重耐药菌提供重要参考。
关键词:  耐药菌  多重耐药性  综述
DOI:10.3969/j.issn.1674-3806.2022.10.06
分类号:R 96;R 378
基金项目:广东省基础与应用基础研究基金项目(编号:2019A1515011197);深圳市科技计划项目(编号:JCYJ20190809115617365);广东省高水平临床重点专科(深圳市配套建设经费)资助(感染性疾病科)(编号:SZGSP011)
A review of drug-resistant mechanisms and treatments of multidrug-resistant bacteria
SUN Li-qin, LIU Jia-ye, WANG Hui, et al.
The First Department of Infectious Diseases, National Clinical Research Center for Infectious Diseases, the Third People′s Hospital of Shenzhen and the Second Affiliated Hospital of Southern University of Science and Technology, Guangdong 518100, China
Abstract:
[Abstract] Multidrug-resistant bacteria have become a major public health problem threatening human health worldwide. Improving the ability of identification and treatment effects of multidrug-resistant bacteria infections is still the key measures to deal with multidrug-resistant bacteria in clinical practice. Exploring some new alternative therapies(e.g. bacteriophage) according to different drug-resistant mechanisms is expected to be a breakthrough technology to deal with multidrug-resistant bacteria in the future. This paper reviews the epidemiology, drug-resistant mechanisms and treatments of multidrug-resistant bacteria, as well as their new alternative treatment methods, so as to provide important reference for clinical identification and treatment of multidrug-resistant bacteria.
Key words:  Drug-resistant bacteria  Multiple drug resistance  Review