引用本文:刘子瑜,熊春秋,黄飞凤,黄 宁.宫颈癌患者血液炎性标志物水平变化及其临床意义[J].中国临床新医学,2022,15(10):985-989.
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宫颈癌患者血液炎性标志物水平变化及其临床意义
刘子瑜,熊春秋,黄飞凤,黄 宁
530005 南宁,广西壮族自治区妇幼保健院妇科
摘要:
[摘要] 目的 探讨宫颈癌患者血液炎性标志物水平变化及其临床意义。方法 回顾性分析2017年1月至2020年12月广西壮族自治区妇幼保健院收治的94名宫颈癌患者(宫颈癌组)的临床资料,另选择同期来该院接受检查的94名健康体检者作为对照组。根据宫颈癌患者的临床特征进一步分为不同亚组:鳞癌组(74例)和腺癌组(20例);肿瘤直径<4 cm组(70例)和≥4 cm组(24例);术后病理分期ⅠA~ⅠB2期组(63例)和ⅠB3~ⅢC2期组(31例)。比较各组C-反应蛋白(CRP)、白蛋白(ALB)、中性粒细胞(NEUT)、淋巴细胞(LY)、血小板(PLT)、白细胞(WBC)、C-反应蛋白与白蛋白比值(CAR)、中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)以及预后营养指数(PNI)。结果 与对照组相比,宫颈癌组的ALB、PNI水平更低,CAR、NLR和PLR水平更高,差异有统计学意义(P<0.05)。Pearson相关分析结果显示,PLR与NLR呈正相关(r=0.654,P=0.000),PNI与PLR和NLR呈负相关(r=-0.352,P=0.000;r=-0.250,P=0.000)。腺癌组PLR水平显著高于鳞癌组(P<0.05)。与肿瘤直径<4 cm组相比,≥4 cm组PLT水平更高,差异有统计学意义(P<0.05)。与ⅠA~ⅠB2期组相比,ⅠB3~ⅢC2期组的PLR、PLT更高,差异有统计学意义(P<0.05)。结论 宫颈癌患者CAR、NLR和PLR水平上升,这可能有助于宫颈癌的鉴别诊断。PLR对评估宫颈癌病理分期有一定的指导意义。
关键词:  宫颈癌  血小板与淋巴细胞比值  中性粒细胞与淋巴细胞比值  诊断
DOI:10.3969/j.issn.1674-3806.2022.10.18
分类号:R 737.3
基金项目:广西卫生健康委员会科研课题项目(编号:Z20170779)
Changes of the levels of blood inflammatory markers in patients with cervical cancer and their clinical significances
LIU Zi-yu, XIONG Chun-qiu, HUANG Fei-feng, et al.
Department of Gynaecology, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 530005, China
Abstract:
[Abstract] Objective To investigate the changes of the levels of blood inflammatory markers in patients with cervical cancer and their clinical significances. Methods The clinical data of 94 patients with cervical cancer(the cervical cancer group) who were admitted to Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region from January 2017 to December 2020 were retrospectively analyzed, and 94 healthy individuals who came to the hospital for health check-up during the same period were selected as the control group. According to the clinical characteristics of the cervical cancer patients, they were further divided into different subgroups: squamous cell carcinoma group(74 cases) and adenocarcinoma group(20 cases); tumor diameter <4 cm group(70 cases) and tumor diameter ≥4 cm group(24 cases); postoperative pathological stageⅠA-ⅠB2 group(63 cases) and postoperative pathological stageⅠB3-ⅢC2 group(31 cases). The levels of C-reactive protein(CRP), albumin(ALB), neutrophil(NEUT), lymphocyte(LY), platelet(PLT), white blood cell(WBC), C-reactive protein to albumin ratio(CAR), neutrophil to lymphocyte ratio(NLR), platelet to lymphocyte ratio(PLR) and prognostic nutritional index(PNI) were compared among the groups. Results Compared with those in the control group, the levels of ALB and PNI in the cervical cancer group were low, and the levels of CAR, NLR and platelet to lymphocyte ratio(PLR) in the cervical cancer group were high, and the differences were statistically significant(P<0.05). The results of Pearson correlation analysis showed that PLR was positively correlated with NLR(r=0.654, P=0.000), and PNI was negatively correlated with PLR and NLR(r=-0.352, P=0.000; r=-0.250, P=0.000). The level of PLR in the adenocarcinoma group was significantly higher than that in the squamous cell carcinoma group(P<0.05). Compared with that in the tumor diameter <4 cm group, the level of PLT in the tumor diameter ≥4 cm group was high, and the difference was statistically significant(P<0.05). Compared with those in the postoperative pathological stage ⅠA-ⅠB2 group, the levels of PLR and PLT in the postoperative pathological stageⅠB3-ⅢC2 group were high, and the differences were statistically significant(P<0.05). Conclusion Elevated levels of CAR, NLR and PLR in cervical cancer patients may help in the differential diagnosis of cervical cancer. PLR has certain guiding significance for the pathological staging of cervical cancer.
Key words:  Cervical cancer  Platelet to lymphocyte ratio(PLR)  Neutrophil to lymphocyte ratio(NLR)  Diagnosis