摘要: |
[摘要] 肾脏是肥胖的靶器官之一。肥胖相关性肾小球疾病(ORG)的发病机制复杂,尚未完全了解。其主要治疗方法为减轻患者体重和应用肾素-血管紧张素-醛固酮系统抑制剂,以减少蛋白尿,延缓进展为终末期肾病。该文对ORG的研究进展作一综述。 |
关键词: 肥胖相关性肾小球疾病 发病机制 肾素-血管紧张素-醛固酮系统 脂肪因子 治疗 |
DOI:10.3969/j.issn.1674-3806.2022.10.21 |
分类号:R 589.2;R 692 |
基金项目:广州市科技计划项目(编号:202201020068) |
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Research progress of obesity-related glomerulopathy |
WANG Cong-xiu, GUAN Bao-zhang
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Department of Nephrology, the First Affiliated Hospital of Jinan University, Guangzhou 510000, China
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Abstract: |
[Abstract] Kidney is one of the target organs of obesity. The pathogenesis of obesity-related glomerulopathy(ORG) is complex and has not yet been fully understood so far. At present, the main treatment methods of ORG are weight loss and renin-angiotensin-aldosterone system(RAAS) inhibitors to reduce proteinuria and delay progression to end-stage renal disease in the patients. This paper reviews the research progress of ORG. |
Key words: Obesity-related glomerulopathy(ORG) Pathogenesis Renin-angiotensin-aldosterone system(RAAS) Adipokine Therapy |