引用本文:王聪秀(综述),管保章(审校).肥胖相关性肾小球疾病的研究进展[J].中国临床新医学,2022,15(10):995-998.
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肥胖相关性肾小球疾病的研究进展
王聪秀(综述),管保章(审校)
510000 广州,暨南大学附属第一医院肾内科
摘要:
[摘要] 肾脏是肥胖的靶器官之一。肥胖相关性肾小球疾病(ORG)的发病机制复杂,尚未完全了解。其主要治疗方法为减轻患者体重和应用肾素-血管紧张素-醛固酮系统抑制剂,以减少蛋白尿,延缓进展为终末期肾病。该文对ORG的研究进展作一综述。
关键词:  肥胖相关性肾小球疾病  发病机制  肾素-血管紧张素-醛固酮系统  脂肪因子  治疗
DOI:10.3969/j.issn.1674-3806.2022.10.21
分类号:R 589.2;R 692
基金项目:广州市科技计划项目(编号:202201020068)
Research progress of obesity-related glomerulopathy
WANG Cong-xiu, GUAN Bao-zhang
Department of Nephrology, the First Affiliated Hospital of Jinan University, Guangzhou 510000, China
Abstract:
[Abstract] Kidney is one of the target organs of obesity. The pathogenesis of obesity-related glomerulopathy(ORG) is complex and has not yet been fully understood so far. At present, the main treatment methods of ORG are weight loss and renin-angiotensin-aldosterone system(RAAS) inhibitors to reduce proteinuria and delay progression to end-stage renal disease in the patients. This paper reviews the research progress of ORG.
Key words:  Obesity-related glomerulopathy(ORG)  Pathogenesis  Renin-angiotensin-aldosterone system(RAAS)  Adipokine  Therapy