| 摘要: |
| ［摘要］ 冠状动脉粥样硬化性心脏病是动脉粥样硬化导致器官病变的最常见类型。其中冠状动脉狭窄或闭塞导致的心肌缺血缺氧或坏死而引起的心肌梗死严重威胁人类健康。近年研究表明，间充质干细胞移植治疗心肌梗死取得了一定效果，但同时存在问题及争议。该文就间充质干细胞生物学特性、作用机制、面临问题及展望作一综述。 |
| 关键词: 间充质干细胞 心肌梗死 旁分泌 外泌体 |
| DOI：10.3969/j.issn.1674-3806.2022.12.19 |
| 分类号:R 542 |
| 基金项目:国家自然科学基金项目（编号：8196020325） |
|
| Research progress in the treatment of myocardial infarction with mesenchymal stem cell transplantation |
|
LIU Shu-heng, LIU Mei-lan
|
|
Department of Cardiovascular Medicine, Affiliated Hospital of Yanbian University, Jilin 133000, China
|
| Abstract: |
| ［Abstract］ Coronary atherosclerotic heart disease is the most common type of organ lesions caused by atherosclerosis, among which myocardial infarction caused by myocardial ischemia, hypoxia or necrosis due to coronary artery stenosis or occlusion poses a serious threat to human health. In recent years, studies show that mesenchymal stem cells(MSCs) transplantation has achieved a certain effect in the treatment of myocardial infarction, but there are still some problems and controversies. This paper reviews the biological characteristics, mechanism of action, problems and prospects of MSCs. |
| Key words: Mesenchymal stem cells(MSCs) Myocardial infarction Paracrine Exosome |
