| 摘要: |
| ［摘要］ 椎间盘退变（IDD）引起的腰背痛是致残率较高的疾病之一，其发病往往呈慢性进行性发展，并且具有不可逆性。因此，如何延缓或逆转IDD成为一个新的研究热点，比如基因疗法、干细胞疗法和细胞因子疗法。如今随着转录因子在椎间盘发育过程中的相继发现，将为开发出一种新的椎间盘疗法提供可能。该文就椎间盘发育过程中相关转录因子的作用进行综述。 |
| 关键词: 转录因子 椎间盘退变 脊索细胞 髓核细胞 |
| DOI：10.3969/j.issn.1674-3806.2023.03.05 |
| 分类号:R 681.5 |
| 基金项目:广西科技计划项目（编号：桂科AD21220134）；广西壮族自治区人民医院青年基金项目（编号：YXQNRC2018-2） |
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| Research progress on the role of transcription factors in regulating intervertebral disc development |
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LI Hao-xi, WEI Jian-xun
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Department of Spine Surgery, the People′s Hospital of Guangxi Zhuang Autonomous Region(Guangxi Academy of Medical Sciences), Nanning 530021, China
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| Abstract: |
| ［Abstract］ Lumbar and back pain caused by intervertebral disc degeneration(IDD) is one of the diseases with high disability rate, and its incidence is often chronic, progressive and irreversible. Therefore, how to delay or reverse IDD has become a new research focus, such as gene therapy, stem cell therapy and cytokine therapy. Now, with the discovery of transcription factors in the development of intervertebral discs, it is possible to develop a novel therapy for intervertebral discs. Therefore, the role of transcription factors in the development of intervertebral discs is reviewed in this paper. |
| Key words: Transcription factors Intervertebral disc degeneration(IDD) Notochord cells Nucleus pulposus cells |
