| 摘要: |
| ［摘要］ 目的 分析主观认知下降（SCD）和轻度认知障碍（MCI）默认网络（DMN）的异常改变，揭示其演变规律，以期为阿尔茨海默病（AD）的早期诊断提供影像学依据。方法 纳入SCD患者35例，MCI患者88例，健康对照（HC）者32名。收集受试者的相关临床数据、神经心理学量表评估数据以及3D-T1WI及静息态血氧水平依赖功能磁共振成像（BOLD-fMRI）数据。以后扣带回（PCC）作为种子点，分析SCD、MCI的DMN功能连接变化。结果 与HC组相比，SCD组双侧前扣带回（ACC）的功能连接降低，右侧额下回的功能连接增强；MCI组双侧海马及海马旁回、右侧额上回/左侧ACC、部分右侧颞中回/角回的功能连接降低，右侧中央前回、双侧岛叶/双侧额下回、右侧中扣带回/右腹侧ACC、右侧补充运动区、左侧小脑的功能连接增强。结论 随着疾病的进展，MCI在SCD的DMN功能连接变化的基础上出现了更为广泛的功能连接异常，提示了SCD是介于MCI和正常老年人之间的中间阶段。 |
| 关键词: 阿尔茨海默病 轻度认知障碍 主观认知下降 默认网络 功能磁共振成像 |
| DOI：10.3969/j.issn.1674-3806.2023.04.01 |
| 分类号:R 445.2 |
| 基金项目:国家自然科学基金地区科学基金项目（编号：82060315）；国家自然科学基金青年科学基金项目（编号：82102032）；广西重点研发计划项目（编号：桂科AB22080053） |
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| Study on a resting-state fMRI of default mode network in patients with subjective cognitive decline and mild cognitive impairment |
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WEI Yi-chen, LIANG Ling-yan, LI Xiao-cheng, et al.
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Department of Radiology,the People′s Hospital of Guangxi Zhuang Autonomous Region(Guangxi Academy of Medical Sciences), Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To provide imaging evidence for early diagnosis of Alzheimer′s disease(AD) by analyzing the changes of default mode network(DMN)and its evolution rules in subjective cognitive decline(SCD) and mild cognitive impairment(MCI). Methods A total of 35 SCD patients including 88 MCI patients and 32 healthy controls(HC) were enrolled. The relevant clinical data and Neuropsychological Scale Assessment data as well as the 3D-T1WI and resting-state blood oxygen level-dependent functional magnetic resonance imaging(BOLD-fMRI) data of the subjects were collected. The posterior cingulate cortex(PCC) was used as the seed to analyze the DMN functional connectivity changes of SCD and MCI. Results Compared with those in the HC group, the functional connectivity decreased in bilateral anterior cingulate cortex(ACC) and increased in the right inferior frontal gyrus in the SCD group, and decreased in the bilateral hippocampus, parahippocampal, right superior frontal gyrus/left ACC, part of right middle temporal gyrus/angular gyrus and increased in the right precentral gyrus, the bilateral insular/bilateral inferior frontal gyrus, the right middle cingulate gyrus/ventral anterior cingulate gyrus, the right supplementary motor area and the left cerebellum in the MCI group. Conclusion With the progression of the disease, MCI presents more extensive functional connectivity abnormalities of DMN on the basis of changes of SCD, suggesting that SCD is an intermediate state between MCI and the normal elderly. |
| Key words: Alzheimer′s disease(AD) Mild cognitive impairment(MCI) Subjective cognitive decline(SCD) Default mode network(DMN) Functional magnetic resonance imaging(fMRI) |
