| 摘要: |
| ［摘要］ 目的 分析血清胱抑素C(Cys C)水平与前循环大血管闭塞患者机械取栓后无效再通的关联性。方法 选择2019年2月至2022年5月于华北理工大学附属医院行机械取栓术的急性前循环大血管闭塞的缺血性卒中患者110例，依据术后3个月改良Rankin量表（mRS）评分将其分为有效再通组（mRS评分<3分，49例），无效再通组（mRS评分≥3分，61例）。比较两组患者的一般临床资料，采用多因素logistic回归分析前循环大血管闭塞患者机械取栓后无效再通的危险因素，应用受试者工作特征(ROC)曲线评估Cys C对无效再通的预测价值。结果 术前较高的血清Cys C水平（OR=1.007）和美国国立卫生研究院卒中量表(NIHSS)评分（OR=1.936）是前循环大血管闭塞急性缺血性脑卒中患者机械取栓后无效再通的独立危险因素（P<0.05），且该两指标均有预测无效再通的应用价值（AUC=0.922，AUC=0.884；P<0.05），联合两指标可进一步提高预测效能（AUC=0.962，P<0.05）。结论 血清Cys C水平和NIHSS评分与前循环大血管闭塞患者机械取栓术后的无效再通有关，有助于临床医师评估患者预后，识别机械取栓术的优势患者。 |
| 关键词: 胱抑素C 急性缺血性脑卒中 前循环大血管闭塞 机械取栓 无效再通 |
| DOI：10.3969/j.issn.1674-3806.2023.04.12 |
| 分类号:R 743.32 |
| 基金项目:河北省重点研发计划大健康服务和生物医药专项（编号：162777192） |
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| Analysis on the correlation between serum cystatin C level and futile recanalization in patients with anterior circulation large vessel occlusion after mechanical thrombectomy |
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LI Guan-yi, ZHANG Chun-yang, LI Hong, et al.
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Department of Neurology, Affiliated Hospital of North China University of Science and Technology, Hebei 063000, China
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| Abstract: |
| ［Abstract］ Objective To analyze the correlation between serum cystatin C(Cys C) level and futile recanalization in patients with anterior circulation large vessel occlusion after mechanical thrombectomy. Methods One hundred and ten acute ischemic stroke patients with anterior circulation large vessel occlusion who underwent mechanical thrombectomy in the Affiliated Hospital of North China University of Science and Technology from February 2019 to May 2022 were selected, and according to their Modified Rankin Scale(mRS) scores 3 months after operation, the patients were divided into the effective recanalization group(with mRS scores <3 points, 49 cases) and the futile recanalization group(with mRS scores ≥3 points, 61 cases). The general clinical data were compared between the patients in the two groups. Multivariate logistic regression was used to analyze the risk factors of futile recanalization after mechanical thrombectomy in the patients with anterior circulation large vessel occlusion. Receiver operating characteristic(ROC) curve was used to evaluate the predictive value of Cys C for futile recanalization. Results Higher preoperative serum Cys C level(OR=1.007) and National Institutes of Health Stroke Scale(NIHSS)scores(OR=1.936) were the independent risk factors for futile recanalization in acute ischemic stroke patients with anterior circulation large vessel occlusion after mechanical thrombectomy(P<0.05), and both of the two indicators had the application value of predicting futile recanalization(AUC=0.922, AUC=0.884, P<0.05), and combining the two indicators could further improve the predicting efficiency(AUC=0.962; P<0.05). Conclusion Serum Cys C level and NIHSS score are associated with futile recanalization after mechanical thrombectomy in patients with anterior circulation large vessel occlusion, which is helpful for clinicians to evaluate the prognosis of the patients and identify the patients with advantages of mechanical thrombectomy. |
| Key words: Cystatin C(Cys C) Acute ischemic stroke Anterior circulation large vessel occlusion Mechanical thrombectomy Futile recanalization |
