摘要: |
[摘要] microRNAs(miRNAs)是一组小的非编码RNA,在恶性肿瘤的生物过程中发挥着关键作用。miR-4516是其主要成员之一,在多种肿瘤中异常表达,与肿瘤的侵袭、转移、预后及对化学药物敏感性等密切相关,具有重要的临床研究价值。该文对miR-4516在消化系统肿瘤、胶质母细胞瘤、乳腺癌、视网膜母细胞瘤、甲状腺癌等恶性肿瘤中的研究进展作一综述。 |
关键词: miRNAs miR-4516 恶性肿瘤 |
DOI:10.3969/j.issn.1674-3806.2023.04.23 |
分类号:R 36 |
基金项目:广西壮族自治区卫生健康委科研课题(编号:Z20170310) |
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Research progress of miR-4516 in malignant tumors |
YIN Wu, ZHONG Xiao-gang
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Department of Pathology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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Abstract: |
[Abstract] MicroRNAs(miRNAs) are a group of small non-coding RNAs, which play the key roles in the biological process of malignant tumors. MiR-4516, one of the main members of miRNAs, is abnormally expressed in a variety of tumors and is closely related to tumor invasion, metastasis and prognosis, and is sensitive to chemical drugs, which has important clinical research value. This paper reviews the research progress of miR-4516 in digestive system neoplasm, glioblastoma, breast cancer, retinoblastoma and thyroid cancer. |
Key words: MicroRNAs(miRNAs) MicroRNA-4516(miR-4516) Malignant tumors |