引用本文:杨 洋,董 冲,高 伟.新型冠状病毒奥密克戎变异株感染对儿童活体肝移植早期恢复的影响[J].中国临床新医学,2023,16(10):1021-1026.
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新型冠状病毒奥密克戎变异株感染对儿童活体肝移植早期恢复的影响
杨 洋,董 冲,高 伟
300192 天津,天津市第一中心医院器官移植中心儿童器官移植科
摘要:
[摘要] 目的 探讨新型冠状病毒奥密克戎变异株感染对儿童活体肝移植早期恢复的影响。方法 回顾性分析2022年12月至2023年2月天津市第一中心医院器官移植中心儿童器官移植科完成的19例儿童肝移植病例资料。根据术前1个月内新型冠状病毒感染(COVID-19)核酸检测结果将患儿分为阳性组(8例)和阴性组(11例)。对两组基线资料以及术后早期血常规、肝功能、FK506血药浓度等资料进行分析。结果 阳性组和阴性组的性别、年龄、体重、小儿终末期肝病模型(PELD)评分差异无统计学意义(P>0.05)。两组移植物重量、移植物与受者质量比(GRWR)、供肝冷缺血时间、无肝期、术后呼吸机支持时间、住ICU时间、术后住院时间等差异无统计学意义(P>0.05)。两组术后2周内血常规及肝功能变化趋势差异无统计学意义(P>0.05)。两组受者术后均无COVID-19发生,呼吸道症状、急性排斥反应及FK506血药浓度差异无统计学意义(P>0.05)。结论 新型冠状病毒奥密克戎变异株轻症感染对儿童活体肝移植受者早期恢复无明显影响。
关键词:  新型冠状病毒  奥密克戎变异株  儿童肝移植  活体
DOI:10.3969/j.issn.1674-3806.2023.10.08
分类号:R 657.3
基金项目:国家自然科学基金项目(编号:82170672);天津市医学重点学科(专科)建设项目[津卫科教(2021)492号]
Effect of SARS-CoV-2 Omicron variant infection on early recovery of children undergoing living donor liver transplantation
YANG Yang, DONG Chong, GAO Wei
Department of Pediatric Organ Transplantation, Organ Transplantation Center, Tianjin First Central Hospital, Tianjin 300192, China
Abstract:
[Abstract] Objective To explore the effect of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Omicron variant infection on the early recovery of children undergoing living donor liver transplantation. Methods The case data of pediatric liver transplantation completed by Department of Pediatric Organ Transplantation, Organ Transplantation Center, Tianjin First Central Hospital from December 2022 to February 2023 were retrospectively analyzed. According to the results of COVID-19 nucleic acid tests within 1 month before operation, the pediatric patients were divided into positive group(8 cases) and negative group(11 cases). The baseline data, early postoperative blood routine, liver function and blood concentration of tacrolimus(Tac, or FK506) were analyzed between the two groups. Results There were no significant differences in gender, age, body weight, and pediatric end-stage liver disease(PELD) scores between the positive group and the negative group(P>0.05). There were no significant differences in graft weight, graft to recipient weight ratio(GRWR), cold ischemia time, anhepatic phase, as well as postoperative ventilator support time, intensive care unit(ICU) hospitalization time, and postoperative hospitalization time between the two groups(P>0.05). There were no significant differences in the trends of changes in blood routine and liver function between the two groups within 2 weeks after operation(P>0.05). No COVID-19 occurred in the recipients of both groups after operation, and there were no statistically significant differences in respiratory symptoms, acute rejection and blood concentration of FK506 between the two groups(P>0.05). Conclusion SARS-CoV-2 Omicron variant mild infection has no significant effect on the early recovery of children undergoing living donor liver transplantation.
Key words:  Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)  Omicron variant  Pediatric liver transplantation  Living donor