引用本文:王佳妮,周殿友,武丽娟.细胞焦亡在类风湿关节炎中的研究进展[J].中国临床新医学,2024,17(5):585-589.
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细胞焦亡在类风湿关节炎中的研究进展
王佳妮1,周殿友2,武丽娟3
1.山西医科大学医院管理部,晋中 030600;2.晋城大医院药学部,山西 048006;3.晋城市第二人民医院风湿免疫科,山西 048000
摘要:
[摘要] 类风湿关节炎(RA)是一种以关节滑膜炎症和进行性关节破坏为特征的自身免疫性疾病。该病的发病机制目前尚不明确,而细胞焦亡作为一种近年来新发现的程序性细胞死亡,被证实通过细胞内激酶相互作用释放促炎介质促进RA的发展。该文对细胞焦亡在RA中的研究进展作一综述。
关键词:  类风湿关节炎  细胞焦亡  炎症小体  GSDM蛋白家族
DOI:10.3969/j.issn.1674-3806.2024.05.21
分类号:R 593;R 392
基金项目:晋城市重点科技研发项目(编号:20210120)
Research progress of pyroptosis in rheumatoid arthritis
WANG Jiani1, ZHOU Dianyou2, WU Lijuan3
1.Department of Hospital Management, Shanxi Medical University, Jinzhong 030600, China; 2.Department of Pharmacy, Jincheng General Hospital, Shanxi 048006, China; 3.Department of Rheumatology and Immunology, Jincheng Second People′s Hospital, Shanxi 048000, China
Abstract:
[Abstract] Rheumatoid arthritis(RA) is an autoimmune disease characterized by synovitis and progressive joint destruction. At present, the pathogenesis of RA is unclear, and pyroptosis, as a newly discovered programmed cell death, has been confirmed to promote the development of RA by releasing pro-inflammatory mediators through intracellular kinase interactions. This paper reviews the research progress of pyroptosis in RA.
Key words:  Rheumatoid arthritis(RA)  Pyroptosis  Inflammasome  Gasdermin(GSDM) protein family