| 摘要: |
| ［摘要］ 目的 探讨新辅助化疗对宫颈鳞状细胞癌（鳞癌）CK5/6和p63蛋白表达的影响。方法 对48例临床ⅠB-ⅡB期宫颈鳞癌患者行以顺铂为基础的新辅助化疗3周期，其后3周行手术治疗，观察临床疗效及病理组织学疗效；用免疫组织化学方法检测癌组织化疗前后CK5/6和p63表达情况。结果 新辅助化疗临床总有效率为56%（27/48），病理组织学总有效率为50%（24/48），48例患者化疗前癌组织均弥漫表达CK5/6和p63，阳性表达率均为100%，化疗后有癌残留的46例患者癌组织均表达CK5/6和p63，阳性率均为100%（P≥0.05）,但阳性表达强度均弱于化疗前。结论 新辅助化疗对宫颈鳞癌特异性标记物CK5/6和p63表达无显著影响，CK5/6和p63可用于形态学难确诊的化疗后宫颈鳞癌的诊断与鉴别诊断。 |
| 关键词: 宫颈鳞状细胞癌 新辅助化疗 CK5/6 p63 |
| DOI：10.3969/j.issn.1674-3806.2017.05.06 |
| 分类号:R 737.33 |
| 基金项目:梧州市科学研究与技术开发计划项目（编号:201402065） |
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| The influence of neoadjuvant chemotherapy on the expressions of CK5/6 and p63 in cervical squamous cell carcinoma |
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JI Yu-Yu, LEI Jia, LI Cheng, et al
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Department of Pharmacy, Wuzhou Red Cross Hospital, Guangxi 543002, China
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| Abstract: |
| ［Abstract］ Objective To study the influence of neoadjuvant chemotherapy(NACT) on the expression of CK5/6 and p63 in cervical squamous cell carcinoma.Methods Three cycles Cisplminbased NACT were given to 48 patients with cervical cancer stage ⅠB-ⅡB and the patients received radical hysterectomy three weeks after the treatment. The clinical and histopathological response were observed, and the expressions of CK5/6 and p63 in the samples of cancer tissues were detected before and after NACT using immunohistochemical staining method.Results After NACT, the total clinical response rate(PR) was 56%（27/48）, and the histopathological response rate was 50%（24/48）. The CK5/6 and p63 were positively expressed in a diffuse and strong manner in all of the 48 samples(100%) before NACT, and were diffusely expressed in all of the 46 samples(100%) with residual cancer after NACT（P>0.05）. The expression intensity in the patients after NACT was weaker than that before NACT.Conclusion There is no significant influence of NACT on the expressions of CK5/6 and p63 in cervical squamous cell carcinoma. The biological markers of CK5/6 and p63 are useful on the diagnosis of cervical squamous cell carcinoma after accepting NACT. |
| Key words: Cervical squamous cell carcinoma Neoadjuvant Chemotherapy CK5/6 p63 |
