| 摘要: |
| ［摘要］ 糖尿病肾病（diabetic kidney disease,DKD）是糖尿病最常见的微血管病变之一，是导致终末期肾病（end-stage renal disease,ESRD）及相关死亡的主要原因。DKD发病机制目前尚未十分明确，但糖尿病患者长期血糖控制不佳是DKD发生、发展的主要决定因素。糖化血红蛋白（glycolated hemoglobin,HbA1c）作为反映糖尿病患者血糖控制情况的“金标准”，研究表明其不仅有可能成为独立预测DKD的风险因素，而且在DKD早期筛查诊治起重要作用；HbA1c平稳且达标是影响DKD进展及预后的重要因素。 |
| 关键词: 糖化血红蛋白 糖尿病 糖尿病肾病 |
| DOI：10.3969/j.issn.1674-3806.2018.01.29 |
| 分类号:R 587.2 |
| 基金项目:广东省医学科研基金立项项目（编号：A2017341）；大学生科技创新培育专项资金（“攀登计划”专项资金）立项项目（编号：pdjh2017b0229） |
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| Glycolated hemoglobin and diabetic kidney disease |
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WU Xiao-cong, WU Ge
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Department of Endocrinology, the Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
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| Abstract: |
| ［Abstract］ Diabetic kidney disease(DKD), one of the most common microvascular complications of diabetes, is the leading cause of end-stage renal disease(ESRD) and death. The pathogenesis of DKD is not yet clear, but poorly controlled frequent high blood glucose leads to occurrence and development of DKD. Glycolated hemoglobin(HbA1c) is the “gold standard” that reflects the control of blood glucose in diabetic patients. HbA1c is not only likely to be an independent predictor of DKD, but also plays an important role in early diagnosis and treatment of DKD. Well-controlled HbA1c is an important factor affecting the progress and prognosis of DKD. |
| Key words: Glycolated hemoglobin(HbA1c) Diabetes Diabetic kidney disease(DKD) |
