| 摘要: |
| ［摘要］ 目的 探讨米索前列醇宫腔内给药联合缩宫素预防剖宫产后出血的疗效。方法 将2014-05～2017-05在该院行剖宫产分娩的妇女300例按随机数字表法分为两组各150例，对照组待胎儿娩出后宫体注射缩宫素10 U，同时以缩宫素20 U加入500 ml葡萄糖中静脉滴注；研究组则宫体注射缩宫素10 U，并将米索前列醇片0.4 mg置于宫腔内，比较两组产妇术中出血量、术后2 h累计出血量、术后24 h总出血量、产后出血发生情况、第三产程时间及产妇不良反应发生情况。结果 研究组术中出血量、术后2 h出血量、术后24 h出血量均明显少于对照组（P<0.05）。研究组产后出血发生率明显低于、第三产程时间明显短于对照组（P<0.05）。两组均未出现其他明显的不良反应。结论 剖宫产术中米索前列醇宫腔内给药联合缩宫素预防产后出血的疗效显著，安全性高，值得临床推广应用。 |
| 关键词: 米索前列醇 缩宫素 产后出血 剖宫产 |
| DOI：10.3969/j.issn.1674-3806.2018.03.06 |
| 分类号:R 714.46 |
| 基金项目:防城港市科学研究与技术开发计划项目 |
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| Efficacy of intrauterine misoprostol administration combined with oxytocin in prevention of postpartum hemorrhage after cesarean section |
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LIU Wei-man
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Department of Gynecology and Obstetrics, the First People′s Hospital of Fangchenggang City, Guangxi 538021, China
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| Abstract: |
| ［Abstract］ Objective To explore the efficacy of intrauterine misoprostol administration combined with oxytocin in prevention of postpartum hemorrhage after cesarean section.Methods From May 2014 to May 2017, three hundred women undergoing cesarean section were randomly divided into two group, with 150 cases in each group. Oxytocin 10 U was injected into the uterine body after the babies were delivered in the control group, followed by intravenous infusion of oxytocin 20 U added into 500 ml glucose injection. Oxytocin 10 U was injected into the uterine body after the babies were delivered in the research group, followed by intrauterine misoprostol administration 0.4 mg. The amount of bleeding during operation, postpartum 2 hours and postpartum 24 hours, the incidence of postpartum hemorrhage, duration of third stage and adverse reactions were compared between the two groups.Results The amount of bleeding during operation, postpartum 2 hours and postpartum 24 hours in the research group were significantly less than those in the control group(P<0.05). The incidence of postpartum hemorrhage and duration of third stage in the research group were significantly lower or shorter than those in the control group(P<0.05). There was no obvious adverse reaction in the two groups.Conclusion Intrauterine misoprostol administration combined with oxytocin is safe and effective in prevention of postpartum hemorrhage after cesarean section. |
| Key words: Misoprostol Oxytocin Postpartum hemorrhage Cesarean section |
